RT Journal Article
T1 Size Control of Chiral Nanospheres Obtained via Nanoprecipitation of Helical Poly(phenylacetylene)s in the Absence of Surfactants
A1 Núñez Martínez, Manuel
A1 Fernández Míguez, Manuel
A1 Quiñoá Cabana, Emilio
A1 Freire Iribarne, Félix Manuel
AB Nanostructuration of dynamic helical polymers such as poly(phenylacetylene)s (PPAs) depends on the secondary structure adopted by the polymer and the functional group used to connect the chiral pendant to the PPA backbone. Thus, while PPAs with dynamic and flexible scaffolds (para- and meta-substituted, ω1<165°) generate by nanoprecipitation low polydisperse nanospheres with controllable size at different acetone/water mixtures, those with a quasi-static behavior and the presence of an extended, almost planar structure (ortho-substituted, ω1>165°), aggregate into a mixture of spherical and oval nanostructures whose size is not controlled. Photostability studies show that poly(phenylacetylene) particles are more stable to light irradiation than when dissolved macromolecularly. Moreover, the photostability of the particle depends on the secondary structure of the PPA and its screw sense excess. This fact, in combination with the encapsulation ability of these polymer particles, allows the creation of light stimuli-responsive nanocarriers, whose cargo can be delivered by light irradiation.
PB Wiley
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34993
UL http://hdl.handle.net/10347/34993
LA eng
NO M. Núñez-Martínez, M. Fernández-Míguez, E. Quiñoá, F. Freire, Angew. Chem. Int. Ed. 2024, 63, e202403313. https://doi.org/10.1002/anie.202403313
NO Financial support from AEI (PID2022-136848NB-I00), Xunta de Galicia (ED431C 2022/21, Centro Singular de Investigación de Galicia acreditación 2023–2027, ED431G 2023/03, and the European Regional Development Fund (ERDF) and is gratefully acknowledged. M. N.-M. and M. F.-M. thanks MICINN for FPI contracts.
DS Minerva
RD 23 abr 2026