RT Journal Article
T1 Event-related brain potential indexes provide evidence for some decline in healthy people with subjective memory complaints during target evaluation and response inhibition processing
A1 Cid Fernández, Susana
A1 Lindín Novo, Mónica
A1 Díaz Fernández, Fernando
K1 Event-related potentials (ERPs)
K1 Stimulus evaluation
K1 Response inhibition
K1 Subjective memory complaints (SMCs)
K1 Alzheimer’s Disease (AD)
AB In the preclinical stage of the Alzheimer’s disease (AD) continuum, subjects report subjective memory complaints (SMCs), although with the absence of any objective decline, and have a higher risk of progressing to dementia than the general population. Early identification of this stage therefore constitutes a major focus of current AD research, to enable early intervention. In this study, healthy adult participants with high and low SMCs (HSMCs and LSMCs) performed a Go/NoGo task during electroencephalogram (EEG) recording. Relative to LSMC participants, HSMC participants performed the task slower (longer reaction times) and showed changes in the event-related potential (ERP) components associated with response preparation (lower readiness potential -RP- amplitude in the Go condition), and also related to response inhibition processes (lower N2-P3 amplitude in the NoGo condition). In addition, HSMC participants showed lower Go-N2 and NoGo-N2 peak-to-baseline amplitudes, however these results seem to be influenced by a negative tendency overlapping stimulus-related waveforms. The declines observed in this study are mostly consistent with those observed in aMCI participants, supporting the notion of the AD continuum regarding SMC state
PB Elsevier
SN 1074-7427
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26158
UL http://hdl.handle.net/10347/26158
LA eng
NO Neurobiology of Learning and Memory, 182 (2021), 107450
NO This study was supported by grants from the Spanish Government, Ministerio de Economía y Competitividad (PSI2014-55316-C3-3-R; PSI2017-89389-C2-2-R), with FEDER Funds; the Galician Government, Consellería de Cultura, Educación e Ordenación Universitaria, Axudas para a Consolidación e Estruturación de Unidades de Investigación Competitivas do Sistema Universitario de Galicia: GRC (GI-1807-USC); Ref: ED431-2017/27, with FEDER funds; the Galician Government, Consellería de Cultura, Educación e Ordenación Universitaria, Programa de axudas de apoio á etapa de formación posdoutoral (Xunta de Galicia, 2016); Ref: ED481B2016/078-0
DS Minerva
RD 24 abr 2026