RT Journal Article
T1 Clinical characterisation and comorbidities of acquired generalised lipodystrophy: a 14-year follow-up study
A1 Fernández-Pombo, Antía
A1 Prado-Moraña, Teresa
A1 Díaz-López, Everardo Josué
A1 Sánchez Iglesias, Sofía
A1 Castro, Ana I.
A1 Cobelo Gómez, Silvia
A1 Araujo-Vilar, David
K1 Acquired generalised lipodystrophy
K1 Adipose tissue
K1 Body composition
K1 Autoimmunity
K1 Diabetes
AB Acquired generalised lipodystrophy (AGL) is a rare disorder characterised by the gradual loss of fat that tends to generalise over time, the origin of which is still not fully clarified. The aim of this study was to offer a detailed description of seven patients with AGL (five women, 33.8 ± 18.6 years of age), evaluated over the last 14 years, in order to augment the knowledge of this disorder. The onset of the phenotype occurred during childhood and adolescence in five cases, and in adulthood in two cases. Three patients reported infections or vaccine administration prior to the development of lipodystrophy, and two subjects reported nodular swelling. The most frequent physical features were phlebomegaly, umbilical protrusion/hernia, and acanthosis nigricans. Skinfolds and body composition analysis showed the generalised absence of fat, with the exception of one patient in whom fat loss was spared in the trunk. The loss of fat in the palms/soles was observed in five subjects. Regarding metabolic comorbidities, throughout follow-up, two patients developed type 1 diabetes and one type 2 diabetes; three also presented hypertriglyceridaemia, one of whom developed acute pancreatitis, and no macrovascular complications were observed. Only one patient showed decreased complement C4. Autoimmunity was present in all cases, and six patients manifested Hashimoto’s thyroiditis, type 1 diabetes, autoimmune hepatitis, and/or celiac disease. Thus, there are certain clinical characteristics of AGL that may be considered important diagnostic criteria to differentiate this disorder from other lipodystrophy subtypes
PB MDPI
YR 2023
FD 2023-11-27
LK http://hdl.handle.net/10347/32594
UL http://hdl.handle.net/10347/32594
LA eng
NO Fernandez-Pombo, A.; Prado-Moraña, T.; Diaz-Lopez, E.J.; Sanchez-Iglesias, S.; Castro, A.I.; Cobelo-Gomez, S.; Araujo-Vilar, D. Clinical Characterisation and Comorbidities of Acquired Generalised Lipodystrophy: A 14-Year Follow-Up Study. J. Clin. Med. 2023, 12, 7344. https:// doi.org/10.3390/jcm12237344
NO This study was supported by the Instituto de Salud Carlos III (grant PI22/00514), co-funded by the European Union, and an intramural grant from the Xunta de Galicia, ED431B 2020/37. A.F.-P. receives funding from the Fundación Alfonso Martín Escudero. S.S.-I. was awarded a Research Fellowship, granted by the Asociación Española de Familiares y Afectados de Lipodistrofias (AELIP)
DS Minerva
RD 24 abr 2026