RT Journal Article
T1 Alginate aerogels by spray gelation for enhanced pulmonary delivery and solubilization of beclomethasone dipropionate
A1 Duong, Thoa
A1 Vivero López, María
A1 Ardao Palacios, Inés
A1 Álvarez Lorenzo, Carmen
A1 Forgács, Attila
A1 Kalmár, József
A1 García González, Carlos A.
K1 Pulmonary drug delivery
K1 Supercritical fluids
K1 Aerogels
K1 Hydration
K1 Beclomethasone dipropionate
AB Aerogel technology is an emerging platform that offers alternative and cost-effective dry carriers with advanced performances for the pharmaceutical industry. The innovative combination of compressed air-assisted spray gelation and “green” supercritical fluid (SCF) technology was used in this study to produce alginate aerogel microparticles with adequate properties for pulmonary drug delivery. Beclomethasone dipropionate (BDP), a poorly water-soluble anti-inflammatory drug for asthma treatment, was loaded into alginate aerogel particles by SCF-assisted impregnation ensuring high loading, as well as the amorphization of the drug. The production of aerogels was optimized through the fine-tuning of parameters in compressed air-assisted spray gelation, specifically adjusting the air flow rate and the pump speed. Alginate aerogels were aimed to be produced with an appropriate aerodynamic diameter from 1 to 5 µm, measured by in vitro deposition tests with Next Generation impactor and potential for deep lung penetration. Nuclear magnetic resonance (NMR) relaxometry was used to assess aerogel hydration and unveiled structure–property relationships leading to the sudden release of the drug. Finally, in vitro cytotoxicity tests in fibroblasts and ex vivo permeability tests were conducted. These biological tests confirmed the excellent biocompatibility of the aerogel formulations and demonstrated the efficient deposition of BDP in porcine bronchial tissues assisted by the porous alginate aerogel carrier
PB Elsevier
SN 1385-8947
YR 2024
FD 2024
LK http://hdl.handle.net/10347/33693
UL http://hdl.handle.net/10347/33693
LA eng
NO Chemical Engineering Journal, Volume 485, 2024, 149849
NO Work supported by MICINN [PID2020-120010RB-I00/AEI/10.13039/501100011033], Xunta de Galicia [ED431C 2020/17], Agencia Estatal de Investigación [AEI] and FEDER funds. This publication is based on work from AERoGELS COST Action (ref. CA18125) supported by COST (European Cooperation in Science and Technology). Th. D. acknowledges the support of Diputación Provincial de A Coruña for research in health science 2022-2023 (BINV-CS/2022) and of AERoGELS COST Action (ref. CA18125) for a Short Term Scientific Missions (STSM) grant, enabling for the collaboration with HUN-REN-DE Mechanisms of Complex Homogeneous and Heterogeneous Chemical Reactions Research Group, Department of Inorganic and Analytical Chemistry, University of Debrecen (Hungary). The authors would like to thank Ezequiel Vázquez Fernández (University of Santiago de Compostela, Spain), Laura Juhász and Krisztián Moldován (University of Debrecen, Hungary) for their valuable support and technical help with Raman spectroscopy, X-ray diffraction, IR-ATR and SEM analyses
DS Minerva
RD 24 abr 2026