RT Dissertation/Thesis
T1 Identification and characterization of Digoxin as a novel senolytic drug
A1 Picallos Rabina, Mª del Pilar
K1 Senescence
K1 cancer
K1 aging
K1 senolytics
K1 chemotherapy
AB Cellular senescence is a potent protective response against severalpotentially dangerous stimuli that prevent the progression of damaged cells by inducing a stable proliferative arrest.In this way, cancer cells need to avoid this response in order to grow and form tumors. However, in recent years ithas been described that senescent cells remain active and secrete a large number of factors to their environmentwith antagonistic activities. In some cases, these factors may have a reinforcing effect on senescence, but in othercases they may have a protumoral activity. For this reason, new approaches have been emerged to specificallyeliminate these senescent cells by using senolytics. In this thesis, we performed a high-throughput screening of achemical library to identify novel senolytic compounds. In this way, we identified the family of Cardiac Glycosides,and in particular Digoxin, as a promising senolytic drug. We also characterized the potential mechanisms behindthe senolytic effect of Digoxin.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30896
UL http://hdl.handle.net/10347/30896
LA eng
DS Minerva
RD 28 abr 2026