RT Journal Article T1 High-Resolution Mass Spectrometry for the Comprehensive Characterization of Plant-Pigment-Based Tattoos and Dyes Formulations A1 Rubio Lareu, Laura A1 García Jares, Carmen María A1 Lores Aguín, Marta K1 Henna K1 Jagua K1 Temporary tattoos K1 Natural tattoo ingredients K1 Dyes K1 High-performance liquid chromatography K1 Quadrupole time-of-flight mass spectrometry AB There has been little research on emerging natural-pigment-based temporary tattoos and their constituents so far. This study focused on the characterization of natural henna and jagua tattoos and dyes in commercial samples. Sample manipulation and treatment were minimal to analyze natural pigments as they are marketed. The characterization of active compounds was performed by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). A novel untargeted characterization was also applied for these types of samples, searching for compounds ranging from the original ingredients to other additives of interest they may contain. The fact that these products may also be a source of unlabelled allergens was considered. This work showed that not all of the 34 samples analyzed contained their characteristic active ingredients, and in addition, 70 substances of a different nature were found. Therefore, a rapid and high-throughput methodology has been developed for the identification of the components of these dyes, providing a necessary approach for quality control or identification of suspicious substances PB MDPI YR 2021 FD 2021 LK http://hdl.handle.net/10347/26675 UL http://hdl.handle.net/10347/26675 LA eng NO Cosmetics 2021, 8(2), 55; https://doi.org/10.3390/cosmetics8020055 NO This research was supported by projects EQC2018-005011-P (Ministry of Science, Innovation and Universities, Spain) and ED431 2020/06 (Xunta de Galicia). The authors belong to the CRETUS Strategic Partnership (ED431E 2018/01). All these programs are co-funded by FEDER (UE). L.R. acknowledges Xunta de Galicia for her predoctoral contract (ED481A-2018/227) DS Minerva RD 23 abr 2026