RT Journal Article
T1 Computer aided volumetric assessment of orbital structures in patients with Graves' orbitopathy: correlation with serum thyroid antiperoxidase antibodies and disease activity
A1 Paniagua Fernández, Laura
A1 Bande, Manuel F.
A1 Abalo Lojo, Jose M.
A1 González García, Francisco
K1 Graves’ orbitopathy
K1 Graves-Basedow
K1 Thyroid
K1 Thyroid hormones
K1 Orbit
AB Introduction: Graves' disease is an autoimmune disorder. Goiter and Graves' orbitopathy are frequently seen clinically. It would be helpful for the diagnosis, grading, prognosis, and treatment of this condition if it was possible to find serum biomarkers to establish a connection between the plasma levels of these compounds and orbital changes.Methods: A retrospective study was performed by revising the medical records of 44 patients with Graves' orbitopathy and 15 controls. The Osirix software (Pixmeo, Geneva, Switzerland) was used for manual orbital measurements. Plasma levels of Graves' orbitopathy substances were obtained in the analytical review of the patients.Results: A greater muscle volume was observed in patients with Graves' orbitopathy in relation to the control group (p < 0.001). The clinical activity score (CAS) was associated to total muscle mass (p = 0.013) and retrorbital fat (p = 0.048). Our results indicated a direct relationship between serum concentrations of anti-thyroid peroxidase antibodies and inferior rectus thickening (p = 0.036); however, we did not observe a positive correlation between other muscle volumes and serum concentrations of various thyroid-related substances.Conclusions: This study is the first that uses Osirix measurement software to manually assess orbital features in patients with Graves' orbitopathy. These measurements were compared to the outcomes of tests performed in a laboratory. Among several serum biomarkers, anti-thyroid peroxidase appears to be a reliable biomarker that correlates positively with inferior rectus muscle thickness in patients with thyroid eye disease. This may help to improve the management of this disease
PB Springer
SN 0165-5701
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30855
UL http://hdl.handle.net/10347/30855
LA eng
NO Paniagua L, Bande MF, Abalo-Lojo JM, Gonzalez F. Computer aided volumetric assessment of orbital structures in patients with Graves' orbitopathy: correlation with serum thyroid antiperoxidase antibodies and disease activity. Int Ophthalmol. 2023 Jun 20. doi: 10.1007/s10792-023-02745-8. Epub ahead of print. PMID: 37338774.
NO Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was financially supported by ISCIII (RETICS RD16/0008/0003) and the European Union (European Regional Development Fund—ERDF)
DS Minerva
RD 3 may 2026