RT Journal Article
T1 Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages
A1 Fernández Mariño, Iago
A1 Anfray, Clément
A1 Crecente Campo, José
A1 Maeda, Akihiro
A1 Ummarino, Aldo
A1 Teijeiro Valiño, Carmen
A1 Blanco Martínez, Darío
A1 Mpambani, Francis
A1 Poul, Laurence
A1 Devalliere, Julie
A1 Germain, Matthieu
A1 Correa Chinea, Juan Francisco
A1 Fernández Villamarín, Marcos
A1 Allavena, Paola
A1 Fernández Megía, Eduardo
A1 Alonso Fernández, María José
A1 Torres Andón, Fernando
K1 Cancer
K1 Hyaluronic acid
K1 Mannose
K1 Polymeric nanocapsules
K1 Nanoprimer
K1 Tumor-associated macrophages
AB Tumor-associated macrophages (TAMs), a class of immune cells that play a key role in tumor immunosuppression, are recognized as important targets to improve cancer prognosis and treatment. Consequently, the engineering of drug delivery nanocarriers that can reach TAMs has acquired special relevance. This work describes the development and biological evaluation of a panel of hyaluronic acid (HA) nanocapsules (NCs), with different compositions and prepared by different techniques, designed to target macrophages. The results showed that plain HA NCs did not significantly influence the polarization of M0 and M2-like macrophages towards an M1-like pro-inflammatory phenotype; however, the chemical functionalization of HA with mannose (HA-Man) led to a significant increase of NCs uptake by M2 macrophages in vitro and to an improved biodistribution in a MN/MNCA1 fibrosarcoma mouse model with high infiltration of TAMs. These functionalized HA-Man NCs showed a higher accumulation in the tumor compared to non-modified HA NCs. Finally, the pre-administration of the liposomal liver occupying agent Nanoprimer™ further increased the accumulation of the HA-Man NCs in the tumor. This work highlights the promise shown by the HA-Man NCs to target TAMs and thus provides new options for the development of nanomedicine and immunotherapy-based cancer treatments
PB Springer
SN 2190-393X
YR 2022
FD 2022
LK http://hdl.handle.net/10347/30000
UL http://hdl.handle.net/10347/30000
LA eng
NO Fernández-Mariño, I., Anfray, C., Crecente-Campo, J. et al. Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages. Drug Deliv. and Transl. Res. (2022). https://doi.org/10.1007/s13346-022-01265-9
NO Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the 2^2-INTRATARGET project (A20/00028) funded by the ISCIII under the umbrella of the ERA NET EuroNanoMed GA N 723770 of the EU Horizon 2020 Research and Innovation Programme. This work was also supported by the Xunta de Galicia (ED431C 2018/30, and “Centro singular de investigación de Galicia” accreditation 2019 − 2022, ED431G2019/03), and the European Union (European Regional Development Fund-ERDF)
DS Minerva
RD 24 abr 2026