RT Journal Article
T1 A Single Picture Explains Diversity of Hyperthermia Response of Magnetic Nanoparticles
A1 Conde Leborán, Iván
A1 Baldomir Fernández, Daniel
A1 Martínez Boubeta, Carlos
A1 Chubykalo-Fesenko, Oksana
A1 Puerto Morales, María del
A1 Salas, Gorka
A1 Cabrera, David
A1 Camarero, Julio
A1 Teran, Francisco J.
A1 Serantes Abalo, David
K1 Magnetic nanoparticles
K1 Dipolar interactions
K1 Hyperthermia
K1 Monte Carlo
AB Progress in the design of nanoscale magnets for localized hyperthermia cancer therapy has been largely driven by trial-and-error approaches, for instance, by changing of the stoichiometry composition, size, and shape of the magnetic entities. So far, widely different and often conflicting heat dissipation results have been reported, particularly as a function of the nanoparticle concentration. Thus, achieving hyperthermia-efficient magnetic ferrofluids remains an outstanding challenge. Here we demonstrate that diverging heat-dissipation patterns found in the literature can be actually described by a single picture accounting for both the intrinsic magnetic features of the particles (anisotropy, magnetization) and experimental conditions (concentration, magnetic field). Importantly, this general magnetic-hyperthermia scenario also predicts a novel non-monotonic concentration dependence with optimum heating features, which we experimentally confirmed in iron oxide nanoparticle ferrofluids by fine-tuning the particle size. Overall, our approach implies a magnetic hyperthermia trilemma that may constitute a simple strategy for development of magnetic nanomaterials for optimal hyperthermia efficiency.
PB American Chemical Society
YR 2015
FD 2015
LK https://hdl.handle.net/10347/46059
UL https://hdl.handle.net/10347/46059
LA eng
NO J. Phys. Chem. C 2015, 119, 27, 15698–15706
NO This document is the Accepted Manuscript version of a Published Article that appeared in final form in The Journal of Physical Chemistry C, copyright © 2015 American Chemical Society. To access the final published article, see https://doi.org/10.1021/acs.jpcc.5b02555
NO We thank the Centro de Supercomputación de Galicia (CESGA) for the computational facilities. This work was partially supported by the EU (projects FEMTOSPIN, ref. NNP3-SL-2012-281043; and MULTIFUN, ref. 246479), the Spanish Ministry of Economy and Competitiveness (FIS2010-20979-C02-02, MAT2009-08165, MAT2011-23641, MAT2013-47395-C4-3-R, CONSOLIDER CSD2007-00041), Xunta de Galicia (INCITE 08PXIB236052PR and EM2013/037), and Gobierno de la Comunidad de Madrid (NANOFRONTMAG, S2013/MIT-2850). I.C.-L. (BES-2010-033138) acknowledges financial support from FPI subprogram. C.M.-B. (RYC-2008-02054) and F.J.T. (RYC-2011-09617) acknowledge financial support from the “Ramón y Cajal” subprogram.
DS Minerva
RD 23 abr 2026