RT Dissertation/Thesis
T1 Preclinical imaging and biodistribution studies of lipid nanoemulsions
A1 Díez Villares, Sandra
K1 Biodistribution
K1 in vivo fate
K1 non-invasive imaging
K1 lipid nanoemulsions
AB Over the past two decades, nanomedicine has shown great promise forchanging the paradigm of conventional medicine. However, the translation rate of nanomedicines from basicscientific research to clinical application remains relatively low. One of the major concerns for the effective clinicaltranslation is the insufficient understanding of the nanomedicines in vivo behavior. In this regard, non-invasiveimaging is emerging as a promising avenue to address this issue, offering attractive possibilities to monitor thenanoparticle pharmacokinetic profile, the drug delivery process, or the target site accumulation. Within thisframework, the main objective of this thesis is the tailoring of sphingomyelin nanoemulsions with imaging agents(e.g., MR contrast agents, radionuclides, and fluorophores) to explore their in vivo behavior in preclinical models.Biodistribution studies of labeled sphingomyelin nanoemulsions demonstrated their versality to be adapted fordifferent medical needs and provided valuable information about the in vivo fate of these novel nanoplatforms.Altogether, this thesis sheds light on the potential of these lipid nanoemulsions as translational nanomedicines andopens a gate for the development of further preclinical nanotheranostics.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30420
UL http://hdl.handle.net/10347/30420
LA eng
DS Minerva
RD 24 abr 2026