RT Journal Article
T1 Mechanism of interaction between hydroxypropyl cellulose and water in aqueous solutions: Importance of polymer chain length
A1 Martín Pastor, Manuel
A1 Stoyanov, Edmont
K1 1H water ligand observed via gradient spectroscopy (WaterLOGSY)
K1 Diffusion‐oriented spectroscopy (DOSY)
K1 Hydroxypropyl cellulose
K1 Quantitative perfect‐echo Watergate 1H‐NMR
K1 Variable temperature NMR
AB The utilization of hydroxypropyl cellulose (HPC) can be regarded as unexpected with regard to certain applications, such as being employed as a solubility enhancer for poorly soluble drugs and as a solubilizing agent for nano‐suspensions and amorphous solid dispersions. However, the best results were obtained for low‐molecular weight (Mw) HPC grades with a short‐chain structure. Therefore, in this study, seven grades of HPC with different polymer chain lengths (Mw) are analyzed in various aqueous solutions by a combination of 1H quantitative NMR spectroscopy, diffusion NMR spectroscopy, and water ligand observed via gradient spectroscopy; these investigations provide insights into the remarkable solubilizing property of HPC at the molecular and supramolecular levels. Furthermore, the hydration and the water residence time are found to be strongly dependent on the polymer chain length of HPC. The quantitative results obtained herein indicate that HPCs with shorter chain lengths retain smaller amounts of water around their hydrated molecules, as compared to their counterparts with longer chain lengths
PB Wiley
YR 2020
FD 2020
LK http://hdl.handle.net/10347/24323
UL http://hdl.handle.net/10347/24323
LA eng
NO Martin‐Pastor, M, Stoyanov, E. Mechanism of interaction between hydroxypropyl cellulose and water in aqueous solutions: Importance of polymer chain length. J Polym Sci. 2020; 58: 1632– 1641. https://doi.org/10.1002/pol.20200185
DS Minerva
RD 30 abr 2026