RT Journal Article
T1 Dual-Targeted Hyaluronic Acid/Albumin Micelle-Like Nanoparticles for the Vectorization of Doxorubicin
A1 Curcio, Manuela
A1 Díaz Gómez, Luis
A1 Cirillo, Giuseppe
A1 Nicoletta, Fiore Pasquale
A1 Leggio, Antonella
A1 Lemma, Francesca
K1 Hyaluronic acid
K1 Human serum albumin
K1 Polysaccharide-protein conjugate
K1 Micelle-like nanoparticles
K1 Redox-responsive
K1 Active targeting
K1 Cancer therapy
AB Drug targeting of tumor cells is one of the great challenges in cancer therapy; nanoparticles based on natural polymers represent valuable tools to achieve this aim. The ability to respond to environmental signals from the pathological site (e.g., altered redox potential), together with the specific interaction with membrane receptors overexpressed on cancer cells membrane (e.g., CD44 receptors), represent the main features of actively targeted nanoparticles. In this work, redox-responsive micelle-like nanoparticles were prepared by self-assembling of a hyaluronic acid–human serum albumin conjugate containing cystamine moieties acting as a functional spacer. The conjugation procedure consisted of a reductive amination step of hyaluronic acid followed by condensation with albumin. After self-assembling, nanoparticles with a mean size of 70 nm and able to be destabilized in reducing media were obtained. Doxorubicin-loaded nanoparticles modulated drug release rate in response to different redox conditions. Finally, the viability and uptake experiments on healthy (BALB-3T3) and metastatic cancer (MDA-MB-231) cells proved the potential applicability of the proposed system as a drug vector in cancer therapy
PB MDPI
YR 2021
FD 2021
LK http://hdl.handle.net/10347/24738
UL http://hdl.handle.net/10347/24738
LA eng
NO Pharmaceutics 2021, 13(3), 304; https://doi.org/10.3390/pharmaceutics13030304
NO L.D.-G. acknowledges Consellería de Cultura, Educación e Ordenación Universitaria for a postdoctoral fellowship (Xunta de Galicia, Spain; ED481B 2017/063)
DS Minerva
RD 26 abr 2026