RT Journal Article
T1 Thyroid-hormone-induced browning of white adipose tissue does not contribute to thermogenesis and glucose consumption
A1 Johann, Kornelia
A1 Cremer, Anna Lena
A1 Fischer, Alexander W.
A1 Heine, Markus
A1 Rial Pensado, Eva
A1 Resch, Julia
A1 Nock, Sebastian
A1 Virtue, Samuel
A1 Harder, Lisbeth
A1 Oelkrug, Rebecca
A1 Astiz, Mariana
A1 Brabant, Georg
A1 Warner, Amy
A1 Vidal Puig, Antonio
A1 Oster, Henrik
A1 Boelen, Anita
A1 López Pérez, Miguel A.
A1 Heeren, Joerg
A1 Dalley, Jeffrey W.
A1 Backes, Heiko
A1 Mittag, Jens
K1 Brown adipose tissue
K1 Beige adipose tissue
K1 Uncoupling protein 1
K1 Thyroid hormone receptor
K1 Body temperature
K1 Norepinephrine
K1 Sympathetic nervous system
K1 Metabolism
K1 Beta3-adrenergic receptor
K1 Pyrexia
K1 Hyperthermia
K1 Glucose tolerance
AB Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and potentially providing metabolic benefits. Here, we show that browning by TH requires TH-receptor β and occurs independently of the sympathetic nervous system. The beige fat, however, lacks sufficient adrenergic stimulation and is not metabolically activated despite high levels of uncoupling protein 1 (UCP1). Studies at different environmental temperatures reveal that TH instead causes hyperthermia by actions in skeletal muscle combined with a central body temperature set-point elevation. Consequently, the metabolic and thermogenic effects of systemic hyperthyroidism were maintained in UCP1 knockout mice, demonstrating that neither beige nor brown fat contributes to the TH-induced hyperthermia and elevated glucose consumption, and underlining that the mere presence of UCP1 is insufficient to draw conclusions on the therapeutic potential of browning agents
PB Elsevier
SN 2211-1247
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21643
UL http://hdl.handle.net/10347/21643
LA eng
NO Johann, K., Cremer, A. L., Fischer, A.W. et al. (2019). Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. Cell rep, 27, 11, 3385-3400. doi: 10.1016/j.celrep.2019.05.054
NO This work was supported by grants of the Deutsche Forschungsgemeinschaft (MI1242/2-2 and 3-2 Heisenberg Program and MI1242/4-1 and 5-1 SPP1629 “Thyroid TransAct” to J.M.; AS547-1/1 to M.A.; GRK1957 “Adipocyte-Brain-Crosstalk”), Young Active Research in Endocrinology, Bioscientifica Trust (BT-000011), and European Society for Endocrinology to K.J. A.V.-P. and S.V. were funded by the BHF (RG/18/7/33636). M.L. was funded by Xunta de Galicia (2016-PG068) and Ministerio de Economía y Competitividad (MINECO) (SAF2015-71026-R). H.O. is a Lichtenberg Fellow of the Volkswagen Stiftung
DS Minerva
RD 28 abr 2026