RT Journal Article
T1 Developmentally-programmed cellular senescence is conserved and widespread in zebrafish
A1 Silva Álvarez, Sabela da
A1 Guerra Varela, Jorge
A1 Sobrido Cameán, Daniel
A1 Quelle Regaldie, Ana
A1 Barreiro Iglesias, Antón
A1 Sánchez Piñón, Laura
A1 Collado Rodríguez, Manuel
K1 Cellular senescence
K1 Development
K1 Zebrafish
AB Cellular senescence is considered a stress response imposing a stable cell cycle arrest to restrict the growth of damaged cells. More recently however, cellular senescence was identified during mouse embryo development at particular structures during specific periods of time. This programmed cell senescence has been proposed to serve developmental and morphogenetic functions and to potentially represent an evolutionary origin of senescence. Cellular senescence has also been described to take place during bird (chick and quail) and amphibian (xenopus and axoltl) development. Fish however, have been described to show a very narrow and restricted pattern of developmental cell senescence. Here we carried out a detailed characterization of senescence during zebrafish development and found it to be conserved and widespread. Apart from yolk and cloaca, previously described structures, we also identified senescence in the developing central nervous system, intestine, liver, pronephric ducts, and crystalline. Interestingly, senescence at these developing structures disappeared upon treatment with senolytic compound ABT-263, supporting their senescent identity and opening the possibility of studying the contribution of this process to development. In summary, our findings extend the description of developmentally-programmed cell senescence to lower vertebrates contributing to the notion of the relevance of this process for embryo development
PB Impact Journals
YR 2020
FD 2020
LK http://hdl.handle.net/10347/26112
UL http://hdl.handle.net/10347/26112
LA eng
NO Da Silva-Álvarez S, Guerra-Varela J, Sobrido-Cameán D, Quelle A, Barreiro-Iglesias A, Sánchez L, Collado M. Developmentally-programmed cellular senescence is conserved and widespread in zebrafish. Aging (Albany NY). 2020; 12:17895-17901. https://doi.org/10.18632/aging.103968
NO Funding at the laboratory of M.C. is provided by the Ministerio de Ciencia, Innovación y Universidades, Fondos Europeos de Desarrollo Regional (FEDER) (RTI2018-095818-B-100). Work in the laboratory of A.B.-I. was funded by grants from the Xunta de Galicia (2016-PG008) and the crowdfunding platform Precipita (FECYT; 2017-CP081). Funding at laboratory of L.S. is provided by Xunta de Galicia (ED431C2018/28)
DS Minerva
RD 28 abr 2026