RT Dissertation/Thesis
T1 Exploring the regulatory roles of transposable elements in the context of long-range TE-gene chromatin interactions in human cancer
A1 Otero Coto, Iago
K1 transposable elements
K1 cancer
K1 genome
K1 3D
AB Transposable elements (TEs) are mobile DNA sequences that comprise over 45% of the human genome. While the majority are currently inactive, some TE families have active copies still mobilising today. When they insert in a new location, a vast variety of genomic alterations can arise which can lead to disease and cancer. Furthermore, TEs incapable of mobilisation can also play a role in genome regulation. Many TEs carry regulatory sequences that can act as enhancers, alternative promoters, and even insulators. In this thesis, we study the effects of these TE-derived regulatory elements in lung cancer taking into account the 3D organisation of the genome. We captured tumour-specific 3D contacts involving TE-derived regulatory elements and found changes in gene expression associated with their spatial proximity.
YR 2026
FD 2026
LK https://hdl.handle.net/10347/47311
UL https://hdl.handle.net/10347/47311
LA eng
DS Minerva
RD 22 may 2026