RT Journal Article
T1 Association of Salivary Human Papillomavirus Infectionand Oral and Oropharyngeal Cancer: A Meta-Analys
A1 Rapado González, Óscar
A1 Martínez-Reglero, Cristina
A1 Salgado Barreira, Ángel
A1 Rodríguez Fernández, Almudena
A1 Aguín Losada, Santiago
A1 Leon-Mateos, Luis
A1 Muinelo Romay, Laura
A1 López López, Rafael
A1 Suárez Cunqueiro, María Mercedes
K1 Human Papillomavirus
K1 Oral cancer
K1 Oropharyngeal cancer
K1 Saliva
K1 Meta-analysis
AB Background. Human papillomavirus (HPV) infection has been recognized as an important risk factor in cancer. The purpose of this systematic review and meta-analysis was to determine the prevalence and effect size of association between salivary HPV DNA and the risk of developing oral and oropharyngeal cancer. Methods. A systematic literature search of PubMed, EMBASE, Web of Science, LILACS, Scopus and the Cochrane Library was performed, without language restrictions or specified start date. Pooled data were analyzed by calculating odds ratios (ORs) and 95% confidence intervals (CIs). Quality assessment was performed using the Newcastle–Ottawa Scale (NOS). Results. A total of 1672 studies were screened and 14 met inclusion criteria for the meta-analysis. The overall prevalence of salivary HPV DNA for oral and oropharyngeal carcinoma was 43.2%, and the prevalence of salivary HPV16 genotype was 27.5%. Pooled results showed a significant association between salivary HPV and oral and oropharyngeal cancer (OR = 4.94; 2.82−8.67), oral cancer (OR = 2.58; 1.67−3.99) and oropharyngeal cancer (OR = 17.71; 6.42−48.84). Significant associations were also found between salivary HPV16 and oral and oropharyngeal cancer (OR = 10.07; 3.65−27.82), oral cancer (OR = 2.95; 1.23−7.08) and oropharyngeal cancer (OR = 38.50; 22.43−66.07). Conclusions. Our meta-analysis demonstrated the association between salivary HPV infection and the incidence of oral and oropharyngeal cancer indicating its value as a predictive indicator
PB MDPI
YR 2020
FD 2020-05-01
LK http://hdl.handle.net/10347/32747
UL http://hdl.handle.net/10347/32747
LA eng
NO Rapado-González, Ó., Martínez-Reglero, C., Salgado-Barreira, Á., Rodríguez-Fernández, A., Aguín-Losada, S., León-Mateos, L., Muinelo-Romay, L., López-López, R., & Suarez-Cunqueiro, M. M. (2020). Association of Salivary Human Papillomavirus Infection and Oral and Oropharyngeal Cancer: A Meta-Analysis. Journal of clinical medicine, 9(5), 1305. https://doi.org/10.3390/jcm9051305
DS Minerva
RD 30 abr 2026