RT Journal Article
T1 Nanotechnologies for the delivery of biologicals: historical perspective and current landscape
A1 Durán-Lobato, Matilde
A1 López Estévez, Ana María
A1 Cordeiro, Ana Sara
A1 Gómez Dacoba, Tamara
A1 Crecente Campo, José
A1 Torres López, Dolores
A1 Alonso Fernández, María José
K1 Drug delivery
K1 Protein delivery
K1 Peptide delivery
K1 mAbs
K1 Transmucosal
K1 Oral
K1 Nasal
K1 Vaccine
K1 Oncologicals
AB Biological macromolecule-based therapeutics irrupted in the pharmaceutical scene generating a great hope due to their outstanding specificity and potency. However, given their susceptibility to degradation and limited capacity to overcome biological barriers new delivery technologies had to be developed for them to reach their targets. This review aims at analyzing the historical seminal advances that shaped the development of the protein/peptide delivery field, along with the emerging technologies on the lead of the current landscape. Particularly, focus is made on technologies with a potential for transmucosal systemic delivery of protein/peptide drugs, followed by approaches for the delivery of antigens as new vaccination strategies, and formulations of biological drugs in oncology, with special emphasis on mAbs. Finally, a discussion of the key challenges the field is facing, along with an overview of prospective advances are provided
PB Elsevier
YR 2021
FD 2021
LK http://hdl.handle.net/10347/27687
UL http://hdl.handle.net/10347/27687
LA eng
NO Advanced Drug Delivery Reviews 176 (2021) 113899. https://doi.org/10.1016/j.addr.2021.113899
NO This work was supported by the Spanish Ministry of Science, Innovation and Universities (Ref.SAF2017-86634-R), the government of Xunta de Galicia (Competitive Reference Groups, Ref:ED431C2017/09), and MINECO- PCIN-2017-129/ AEI, under the frame of EuroNanoMed III. M. Durán-Lobato acknowledges a postdoctoral contract granted by “VI Plan Propio” from the University of Seville (grant number USE-19533-Y), and Ana M. López-Estévez acknowledges a predoctoral FPU grant from the Spanish Ministry of Science, Innovation and Universities (grant number FPU18/00095)
DS Minerva
RD 28 abr 2026