RT Journal Article
T1 Surface-enhanced raman scattering surface selection rules for the proteomic liquid biopsy in real samples: Efficient detection of the oncoprotein c-MYC
A1 Pazos Chantrero, Elena
A1 García-Algar, Manuel
A1 Penas Tallón, Cristina
A1 Nazarenus, Moritz
A1 Torruella, Arnau
A1 Pazos-Pérez, Nicolás
A1 Guerrini, Luca
A1 Vázquez Sentís, Marco Eugenio
A1 García-Rico, Eduardo
A1 Mascareñas Cid, José Luis
A1 Álvarez-Puebla, Ramón A.
K1 Blood-based biomarkers
K1 Diagnosis
K1 Cancers
K1 SERS
AB Blood-based biomarkers (liquid biopsy) offer extremely valuable tools for the noninvasive diagnosis and monitoring of tumors. The protein c-MYC, a transcription factor that has been shown to be deregulated in up to 70% of human cancers, can be used as a robust proteomic signature for cancer. Herein, we developed a rapid, highly specific, and sensitive surface-enhanced Raman scattering (SERS) assay for the quantification of c-MYC in real blood samples. The sensing scheme relies on the use of specifically designed hybrid plasmonic materials and their bioderivatization with a selective peptidic receptor modified with a SERS transducer. Peptide/c-MYC recognition events translate into measurable alterations of the SERS spectra associated with a molecular reorientation of the transducer, in agreement with the surface selection rules. The efficiency of the sensor is demonstrated in cellular lines, healthy donors and a cancer patient
PB American Chemical Society
SN 0002-7863
YR 2016
FD 2016-10-12
LK http://hdl.handle.net/10347/15020
UL http://hdl.handle.net/10347/15020
LA eng
NO J. Am. Chem. Soc., 2016, 138 (43), pp 14206–14209
NO NOTICE: This is the peer reviewed version of the following article: Elena Pazos, Manuel García-Algar,Cristina Penas, Moritz Nazarenus, Arnau Torruella, Nicolas Pazos-Perez, Luca Guerrini, M. EugenioVázquez, Eduardo Garcia-Rio*, José L. Macareñas* and Ramon A. Alvarez-Puebla* (2016), SERS SurfaceSelection Rules for the Proteomic Liquid Biopsy in Real Samples: Efficient Detection of the Oncoprotein cMYC.J. Am. Chem. Soc., 138, 14206-14209 [DOI: 10.1021/jacs.6b08957]. This article may be used fornon-commercial purposes in accordance with ACS Publications Terms and Conditions for self-archiving
NO This work was funded by Marie Curie Actions (FP7/2007-2013, TECNIOspring no. 600388 and PrioSERS FP72014-623527), the European Research Council (Advanced Grant No. 340055), the Spanish MINECO (CTQ2014-59808R, SAF2013-41943-R, CTQ2015-70698-R, CTQ2013-49317-EXP and the orfeo-cinqa network), the Generalitat of Catalonia (2014-SGR-480, AGAUR 2014 052 and AGAUR 2014 054), the Xunta de Galicia (GRC2013-041), and Medcom Advance S.A.
DS Minerva
RD 28 abr 2026