RT Journal Article
T1 Periodontal Condition and Subgingival Microbiota Characterization in Subjects with Down Syndrome
A1 Cuenca, Maigualida
A1 Marín, María José
A1 O'Connor, Ana
A1 Sánchez, María del Carmen
A1 Blanco Carrión, Juan
A1 Limeres Posse, Jacobo
A1 Sanz, Mariano
A1 Diz Dios, Pedro
A1 Herrera, David
K1 Periodontitis
K1 Down syndrome
K1 Polymerase chain reaction
K1 Microbiota
K1 Gingivitis
AB The aim was to study the subgingival microbiota in subjects with Down syndrome (DS) with different periodontal health status, using cultural and molecular microbiological methods. In this cross-sectional study, DS subjects were selected among those attending educational or occupational therapy centers in Galicia (Spain). Medical histories, intraoral and periodontal examinations and microbiological sampling were performed. Samples were processed by means of culture and quantitative polymerase chain reaction (qPCR). Microbiological data were compared, by one-way ANOVA or Kruskal-Wallis and chi-square or Fisher tests, according to their periodontal status. 124 subjects were included, 62 with a healthy periodontium, 34 with gingivitis and 28 with periodontitis. Patients with periodontitis were older (p < 0.01) and showed lower prevalence of hypothyroidism and levothyroxine intake (p = 0.01), presented significantly deeper pockets and more attachment loss (p ≤ 0.01). Both gingivitis and periodontitis subjects showed higher levels of bleeding and dental plaque. PCR counts of T. forsythia and culture counts of E. corrodens and total anaerobic counts were significantly higher in periodontitis patients. Relevant differences were observed in the subgingival microbiota of DS patients with periodontitis, showing higher levels of anaerobic bacteria, T. forsythia and E. corrodens, when compared with periodontally healthy and gingivitis subjects. Moreover, periodontitis subjects were older, had lower frequency of hypothyroidism and higher levels of dental plaque
PB MDPI
YR 2021
FD 2021
LK http://hdl.handle.net/10347/24203
UL http://hdl.handle.net/10347/24203
LA eng
NO Cuenca, M.; Marín, M.J.; Nóvoa, L.; O`Connor, A.; Sánchez, M.d.C.; Blanco, J.; Limeres, J.; Sanz, M.; Diz, P.; Herrera, D. Periodontal Condition and Subgingival Microbiota Characterization in Subjects with Down Syndrome. Appl. Sci. 2021, 11, 778
NO This project was co-funded by Xunta de Galicia under Ignicia Programme, Axencia Galega de Innovación, GAIN (12/08/2016; GRANT_NUMBER: IN855A). The participation of M.C. Sánchez in the project occurred within the activities of the Extraordinary Chair of DENTAID in Periodontal Research, University Complutense of Madrid, Spain
DS Minerva
RD 4 may 2026