RT Journal Article
T1 At-admission HbA1c levels in hospitalized COVID-19 participants with and without known diabetes
A1 Valle, Andrea
A1 Rodríguez García, Javier
A1 Martínez Olmos, Miguel Ángel
A1 Ortolá Devesa, Juan Bautista
A1 Rodríguez-Segade Villamarín, Santiago
K1 CKD chronic kidney disease
K1 COVID-19 coronavirus disease 2019
K1 eGFRestimated glomerular filtration rate
K1 FPG fasting plasma glucose
K1 KD known diabetes
K1 NG normoglycemia
K1 PD prediabetes
K1 RT-PCR real-time polymerase chain reaction
K1 SARS-CoV-2 severe acute respiratory syndrome coronavirus 2
AB Background: To examine glycaemic status, and the impact of at-admission HbA1c levels on outcome, in a large group of participants hospitalized for COVID-19. Methods: We inclued 515 participants with confirmed COVID-19 infection, with or without known diabetes, who met the following additional criteria: 1) age > 18 years, 2) HbA1c was determined at admission; 3) fasting plasma glucose was determined in the week of admission, and 4) discharge or death was reached before the end of the study. We examined attributes of participants at admission and 3–6 months post-discharge. To assess the associations of pre-admission attributes with in-hospital mortality, logistic regression analyses were performed. Results: Mean age was 70 years, 98.8% were of white race, 49% were female, 31% had known diabetes (KD), an additional 7% met the HbA1c criterion for diabetes, and 13.6% died. In participants with KD, FPG and HbA1c levels were not associated with mortality in adjusted analyses; however, in participants without KD, whereas FPG showed direct association with mortality, HbA1c showed slight inverse association. Conclusions: There was a very high prevalence of people without KD with HbA1c levels above normal at-admission. This alteration does not seem to have been related to blood glucose levels
PB Elsevier
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29105
UL http://hdl.handle.net/10347/29105
LA eng
NO Clinica Chimica Acta 532 (2022) 188-192
DS Minerva
RD 24 abr 2026