RT Journal Article
T1 De novo bone formation around implants with a surface based on a monolayer of multi-phosphonate molecules. An experimental in vivo investigation
A1 Sanz Esporrín, Javier
A1 Di Raimondo, Riccardo
A1 Vignoletti, Fabio
A1 Núñez, Javier
A1 Muñoz Guzón, Fernando María
A1 Sanz, Mariano
K1 Animal model
K1 Dental implants
K1 Histology
K1 Implant surface
K1 Osseointegration
K1 Monophosphonate layer
K1 Wound chamber
K1 Histometric analysis
K1 Micro-CT
AB Objectives: The purpose of this experimental in vivo investigation was to evaluate the influence of modifying the implant surface by adding a monolayer of multi-phosphonate molecules on the de novo bone formation and osseointegration.Material and Methods: The study was designed as an animal preclinical trial with intra-animal control and two healing periods, 2 and 8 weeks, to compare implants with an identical macro-design but with two different surfaces. Eight female Beagle dogs participated in the study. Control implants had a moderately rough surface combining sandblasting and acid etching; test implants had an additional monophosphonate layer covalently bonded to titanium. Histologic and radiographic (micro-CT) outcome variables were evaluated.Results:The first bone-to-implant contact (fBIC) was located more coronally for the test implants at the first (0.065 mm (95% CI = −0.82, 0.60)) and second healing milestones (0.17 mm (95% CI = −0.9, 0.55)). Most coronal BIC of the test implants displayed a higher percentage of osseointegration, +6.33% and +13.38% after 2 and 8 weeks, respectively; however, the differences were not statistically significant. The micro-CT examination did not show any BIC difference.Conclusions:The monophosphonate layer coating demonstrated clinical, histological, and radiographic results similar to the control surface.
PB Wiley
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26690
UL http://hdl.handle.net/10347/26690
LA eng
NO Sanz-Esporrin, J., Di Raimondo, R., Vignoletti, F., Núñez, J., Muñoz, F., & Sanz, M. (2021). De novo bone formation around implants with a surface based on a monolayer of multi-phosphonate molecules. An experimental in vivo investigation. Clinical Oral Implants Research, 00, 1– 12. https://doi.org/10.1111/clr.13803
DS Minerva
RD 28 abr 2026