RT Journal Article
T1 Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy
A1 Balakrishnan, Preethi Bala
A1 Silvestri, Niccolò
A1 Fernández Cabada, Tamara
A1 Marinano, Federica
A1 Fernandes, Soraia
A1 Fiorito, Sergio
A1 Miscuglio, Mario
A1 Serantes Abalo, David
A1 Ruta, Sergiu
A1 Livesey, Karen L.
A1 Hovorka, Ondrej
A1 Chantrell, Roy W.
A1 Pellegrino, Teresa
K1 Cancer therapy
K1 Cobalt ferrite nanoparticles
K1 Cobalt toxicity
K1 Magnetic hyperthermia
K1 Particle alignment
AB Nanoparticle‐based magnetic hyperthermia is a well‐known thermal therapy platform studied to treat solid tumors, but its use for monotherapy is limited due to incomplete tumor eradication at hyperthermia temperature (45 °C). It is often combined with chemotherapy for obtaining a more effective therapeutic outcome. Cubic‐shaped cobalt ferrite nanoparticles (Co–Fe NCs) serve as magnetic hyperthermia agents and as a cytotoxic agent due to the known cobalt ion toxicity, allowing the achievement of both heat and cytotoxic effects from a single platform. In addition to this advantage, Co–Fe NCs have the unique ability to form growing chains under an alternating magnetic field (AMF). This unique chain formation, along with the mild hyperthermia and intrinsic cobalt toxicity, leads to complete tumor regression and improved overall survival in an in vivo murine xenograft model, all under clinically approved AMF conditions. Numerical calculations identify magnetic anisotropy as the main Co–Fe NCs’ feature to generate such chain formations. This novel combination therapy can improve the effects of magnetic hyperthermia, inaugurating investigation of mechanical behaviors of nanoparticles under AMF, as a new avenue for cancer therapy
PB Wiley
YR 2020
FD 2020
LK http://hdl.handle.net/10347/24235
UL http://hdl.handle.net/10347/24235
LA eng
NO Balakrishnan, P. B., Silvestri, N., Fernandez‐Cabada, T., Marinaro, F., Fernandes, S., Fiorito, S., Miscuglio, M., Serantes, D., Ruta, S., Livesey, K., Hovorka, O., Chantrell, R., Pellegrino, T., Exploiting Unique Alignment of Cobalt Ferrite Nanoparticles, Mild Hyperthermia, and Controlled Intrinsic Cobalt Toxicity for Cancer Therapy. Adv. Mater. 2020, 32, 2003712. https://doi.org/10.1002/adma.202003712
NO This work was partially funded by the European Research Council (starting grant ICARO, Contract No. 678109) and partially by the AIRC project (Contract No. 14527). The authors also acknowledge Centro de Supercomputación de Galicia (CESGA) for the computational resources. D.S. acknowledges Xunta de Galicia for financial support under the I2C Plan and the Strategic Grouping in Materials (AeMAT; Grant No. ED431E2018/08). This work made use of computational facilities funded by the Small items of research equipment at the University of York ENERGY (Grant No. EP/K031589/1)
DS Minerva
RD 4 may 2026