RT Journal Article
T1 Lichenoid areas may arise in early stages of proliferative verrucous leukoplakia: a long-term study of 34 patients
A1 Barba Montero, Catalina
A1 Lorenzo Pouso, Alejandro Ismael
A1 Gándara Vila, Pilar
A1 Blanco Carrión, Andrés
A1 Marichalar Mendía, Xabier
A1 García García, Abel
A1 Pérez-Sayáns García, Mario
K1 Dysplasia
K1 Malignant transformation
K1 Oral lichen planus
K1 Oral lichenoid lesions
K1 Proliferative verrucous leukoplakia
AB Background: Proliferative verrucous leukoplakia is considered an uncommon oral potentially malignant disorder with a high malignant transformation rate. The objective of this paper was to define its cancer incidence and related risk factors.: Method: A retrospective audit of 34 patients diagnosed with proliferative verrucous leukoplakia from a university-based unit, during the period from 1995 to 2019 was performed. The mean number of visits was 23 ± 18.6. The follow-up was divided into four-time intervals to evaluate the clinical presentation, number of lesions, dysplasia grade, and malignant transformation rate. Results: The majority of patients were females 29 (85.3%), with verrucous component (77.8%), with a gingival presentation (31.8%), and with a preceding lichenoid area (44.1%). Eleven patients (32.4%) were affected by oral cancer during the follow-up, developing a total of 15 carcinomas. The mean age of malignant transformation was 67.2 ± 12.9 years, particularly 8 ± 8.5 from the onset of the lesions. Warty forms presented a higher mean estimate for malignant transformation (15.2 years, 95% confidence interval 4.4–26 years) than nodular forms (1.9 years, 95% confidence interval 1.9–1.9) (p = 0.019). Patients with an initial proliferative verrucous leukoplakia diagnosis suffered a higher risk of malignancy, particularly 15.55 times (95% confidence interval 1.69–143.17; p = 0.015) than those who did present a preceding area with lichenoid morphology. Conclusion: Proliferative verrucous leukoplakia presented a high malignant transformation rate and sometimes displayed preceding oral lichenoid areas in early stages. Further studies are needed to understand the impact of these lichenoid areas in proliferative verrucous leukoplakia progression
PB Wiley
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29278
UL http://hdl.handle.net/10347/29278
LA eng
NO Barba-Montero C, Lorenzo-Pouso AI,Gándara-Vila P, et al. Lichenoid areas may arise in early stagesof proliferative verrucous leukoplakia: A long-term study of 34patients.J Oral Pathol Med. 2022;51(6):573‐581. doi:10.1111/jop.13317
DS Minerva
RD 28 abr 2026