RT Journal Article
T1 Thermoregulable Magnetic Microfluidic Devices by Magnetic Hyperthermia from Iron Oxide Nanoparticles
A1 Paramés Estévez, Santiago
A1 García Acevedo, Pelayo
A1 Radziunas-Salinas, Yago
A1 Piñeiro Redondo, Yolanda
A1 Rivas Rey, José
A1 Flores Arias, María Teresa
A1 Pérez Muñuzuri, Alberto
K1 Organ on a chip
K1 Microfluidics
K1 Computer fluid dynamics (CFD)
K1 Hyperthermia
K1 Magnetic nanoparticles
K1 Thermoregulable
AB Accurate control of energy supplied to a liquid in a controlled environment is essential for automating and optimizing processes. Organs on a chip (OoC) are an emerging technology that allows the design of customized environmental conditions for cells and chemical reactions by creating specific channel shapes while simplifying data acquisition. To thermoregulate these devices and therefore expand their use widely, we integrated iron oxide nanoparticles (IONPs) within the matrix of the chip to heat them by using magnetic hyperthermia. We tested the devices and developed a digital twin that reproduces the experimental OoC-fluid interaction while allowing us to measure parameters that would be inaccessible in a laboratory and get a fullpicture of the heat transfer at the boundary.
PB American Chemical Society
SN 2574-0970
YR 2025
FD 2025-07-11
LK https://hdl.handle.net/10347/43003
UL https://hdl.handle.net/10347/43003
LA eng
NO ACS Appl. Nano Mater. 2025, 8, 14505−14518
NO This research was supported by the Spanish Ministerio de Ciencia e Innovacion and European Regional Development Fund, research grant PID2022-138322OB-I00, and by Xunta de Galicia, Research Grant No ED431B 2023/07 and ED431C 2021/14. P. García-Acevedo thanks Axencia Galega de Innovación (Spain) for his Postdoctoral Grant (Axudas de apoio á etapa de formación posdoutoral-IN606B-2024.1). Yago Radziunas-Salinas thanks the Ministerio for the grant FPU22/01231. The authors also thank Angela Arnosa-Prieto and Bastián Carnero-Groba for their help during the development of this work.
DS Minerva
RD 30 abr 2026