RT Dissertation/Thesis
T1 Análisis de nuevos marcadores moleculares de aplicabilidad clínica en el pronóstico del melanoma uveal: papel de la oncoproteína DJ-1, la senescencia celular y la comunicación microvesicular
A1 Santiago Varela, María
K1 Melanoma uveal/ Uveal melanoma
K1 DJ-1
K1 Senescencia/ Senescence
K1 Exosomas/ Exosomes
AB Malignant uveal melanoma (UM) is the most common primary intraocular tumor in adults. It disseminates primarily through the blood stream and is preferably metastasized in the liver. Even with the successful treatment of UM primary tumors, patients are still at risk for metastases more than 20 years after the initial diagnosis. The aim of this study was to provide new insights on potential biomarkers for UM. We investigated DJ-1 actions in a cell culture, new senescence biomarkers in tissue, and the exosomes as a potential new biomarker in this tumor.
YR 2017
FD 2017
LK http://hdl.handle.net/10347/15607
UL http://hdl.handle.net/10347/15607
LA spa
DS Minerva
RD 23 abr 2026