RT Journal Article
T1 Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices
A1 Cobo Golpe, Miguel
A1 Ramil Criado, María
A1 Cela Torrijos, Rafael
A1 García Martín, Jennifer
A1 Rodríguez Pereiro, Isaac
K1 Ambient ionization
K1 Triclosan
K1 Direct analysis in real time (DART)
K1 Accurate mass spectrometry
K1 Environmental samples
K1 Matrix effects
AB In this work, the applicability of direct analysis in real time coupled to accurate mass spectrometry (DART-MS) to the quantitative determination of triclosan (TCS) in samples with increasing complexity, from personal care products to extracts from sewage, is investigated. In the first term, DART-MS spectra of TCS as free phenol and as derivatized species are characterized; thereafter, the effects of several instrumental variables in the detectability of TCS (i.e., temperature, solvent, and compound holder) are discussed. Under final selected conditions, TCS was determined from its [M-H]− ions, without need of derivatization, attaining an instrumental limit of quantification of 5 ng mL−1, with a linear response range up to 1000 ng mL−1. Complex matrices, such as solid-phase extracts obtained from environmental water samples, moderately inhibited the ionization efficiency of TCS, with signal attenuation percentages in the range of 6 to 57%, depending on the sample type and on the concentration factor provided by the SPE procedure. The accuracy of results obtained by DART-MS was evaluated using liquid chromatography (LC) with MS detection; in both cases, a time-of-flight (TOF) MS instrument was employed for the selective determination of the [M−H]− ions of TCS (m/z values 286.9439 and 288.9410) using a mass window of 20 ppm. DART-MS did not only provide enough sensitivity to detect the presence of TCS in environmental samples (raw and treated wastewater as well as freeze-dried sludge), but also measured concentrations matched those determined by LC-ESI-TOF-MS, with only slightly higher standard deviations. During analysis of personal care products, containing much higher concentrations of TCS in a less complex matrix, both techniques were equivalent in terms of accuracy and precision
PB Springer
SN 1618-2642
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26952
UL http://hdl.handle.net/10347/26952
LA eng
NO Cobo-Golpe, M., García-Martín, J., Ramil, M. et al. Assessment of direct analysis in real time accurate mass spectrometry for the determination of triclosan in complex matrices. Anal Bioanal Chem (2021). https://doi.org/10.1007/s00216-021-03591-2
NO This study was supported by the Spanish Government and Xunta de Galicia through grants PGC2018-094613-B-I00 and ED431C 2021/06, co-funded by the EU. M. Cobo-Golpe thanks the Spanish Ministry of Science, Innovation and Universities for a FPI fellowship
DS Minerva
RD 27 abr 2026