RT Journal Article
T1 The prion 2018 round tables (I): the structure of PrP Sc
A1 Baskakov, Ilia V.
A1 Caughey, Byron
A1 Rodríguez Requena, Jesús
A1 Sevillano, Alejandro M.
A1 Surewicz, Witold K.
A1 Wille, Holger
K1 PrPSc structure
K1 PrPSc syalilation
K1 4-rung β-solenoid
K1 PIRIBS
K1 PrP23-144 infectious amyloid
K1 Cryo-electron microscopy
K1 Solid state NMR
K1 Prion2018
AB Understanding the structure of PrPSc is without doubt a sine qua non to understand not onlyPrPSc propagation, but also critical features of that process such as the strain phenomenonand transmission barriers. While elucidation of the PrPSc structure has been full of difficulties, we now have a large amount of structural information that allows us to begin to understand it. This commentary article summarizes a round table that took place within the Prion 2018 meeting held in Santiago de Compostela to discuss the state of the art in this matter. Two alternative models of PrPSc exist: the PIRIBS and the 4-rung β-solenoid models. Both of them have relevant features. The 4-rung β-solenoid model agrees with experimental constraints of brain derived PrPSc obtained from cryo-EM and X-ray fiber diffraction studies. Furthermore, it allows facile accommodation of the bulky glycans that decorate brain-derived PrPSc. On the other hand, the infectious PrP23-144 amyloid exhibits a PIRIBS architecture. Perhaps, both types of structure co-exist.
PB Taylor & Francis
SN 1933-6896
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21598
UL http://hdl.handle.net/10347/21598
LA eng
NO Ilia V. Baskakov, Byron Caughey, Jesús R. Requena, Alejandro M. Sevillano, Witold K. Surewicz & Holger Wille (2019) The prion 2018 round tables (I): the structure of PrPSc , Prion, 13:1, 46-52, DOI: 10.1080/19336896.2019.1569450
NO Supported by grants BFU2013-48436-C2-1-P and BFU2017- 86692-P from the Spanish Ministries of Economy and Competitiveness and Science, Innovation and Universities, respectively, to JRR and grant 201600029 from the Alberta Prion Research Institute to HW. This work was also supported in part by the Intramural Research Program of the NIAID (BC) and by the National Institute of Health grants R01 NS045585 (IVB), P01 AI106705 (WKS), R01 NS083687 (WKS) and R01 NS103848 (WKS)
DS Minerva
RD 28 abr 2026