RT Dissertation/Thesis
T1 Delivering the Messenger: Engineering Nanoparticles for Advanced mRNA Therapies
A1 Taina González, Laura
K1 mRNA
K1 nanomedicine
K1 gene therapies
K1 LNPs
K1 immuno-oncology
AB Messenger RNA (mRNA) has advanced to the forefront of innovative therapies in the past years. With the approval of COVID-19 vaccines, mRNA has demonstrated its potential in vaccinology.Nevertheless, multiple biomedical applications can benefit from its advantages over other genetic therapies. Unlike DNA therapies, mRNA exerts its action in the cytoplasm, and, therefore, does not integrate into the nucleus of the host, a fact that is translated to higher safety profiles. For the same reason, the delivery of exogenous mRNA is a more efficient process, facilitating its use as a therapeutic. Furthermore, mRNA can be synthesized in the laboratory following straight forward techniques, which, at the same time are adaptable to industrial scale, including for GMP manufacturing. Importantly, mRNA sequence can be modified and  adjusted to specific needs, such as emergency situations or personalized medicine.
YR 2024
FD 2024
LK https://hdl.handle.net/10347/39487
UL https://hdl.handle.net/10347/39487
LA eng
DS Minerva
RD 27 abr 2026