RT Journal Article
T1 A Three-Gene Expression Signature Identifies a Cluster of Patients with Short Survival in Chronic Lymphocytic Leukemia
A1 Mosquera Orgueira, Adrián
A1 Antelo Rodríguez, Beatriz
A1 Díaz Arias, José Ángel
A1 Díaz Varela, Nicolás Antonio
A1 Bello López, José Luis
AB Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder characterized by its heterogeneous clinical evolution. Despite the discovery of the most frequent cytogenomic drivers of disease during the last decade, new efforts are needed in order to improve prognostication. In this study, we used gene expression data of CLL samples in order to discover novel transcriptomic patterns associated with patient survival. We observed that a 3-gene expression signature composed of SCGB2A1, KLF4, and PPP1R14B differentiate a group of circa 5% of cases with short survival. This effect was independent of the main cytogenetic markers of adverse prognosis. Finally, this finding was reproduced in an independent retrospective cohort. We believe that this small gene expression pattern will be useful for CLL prognostication and its association with CLL response to novel drugs should be explored in the future.
PB Hindawi
SN 1687-8450
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21062
UL http://hdl.handle.net/10347/21062
LA eng
NO Mosquera Orgueira, A., Antelo Rodríguez, B., Díaz Arias, J. Á, Díaz Varela, N., & Bello López, J. L. (2019). A three-gene expression signature identifies a cluster of patients with short survival in chronic lymphocytic leukemia. Journal of Oncology, 2019, 1-4. doi:10.1155/2019/9453539
DS Minerva
RD 28 abr 2026