RT Book,_Section
T1 Synthesis and Antiviral Activities of Novel Purinyl- and Pyrimidinylcarbanucleosides Derived from Indan
A1 Alonso Sousa, Nerea
A1 Caamaño Santos, María Olga
A1 Fernández González, Franco
A1 García Mera, Xerardo
A1 Morales Aguilera, Melvin
A1 Rodríguez Borges, José E.
A1 Clercq, Erik de
K1 Synthesis
K1 Indan carbanucleosides
K1 Mitsunobu reaction
K1 Suzuki–Miyaura reaction
K1 Antiviral activity
AB Starting from (±)-trans- and (±)-cis-3-hydroxymethyl-1-indanol, novel 6-substituted purinylcarbanucleoside derivatives of indan (5, 6, 9, 10, 15 and 17) were synthesized through a key coupling reaction with 6-chloropurine under Mitsunobu conditions. Suzuki–Miyaura reactions of the protected 6-chloropurine derivative with different arylboronic acids afforded the corresponding 6-arylpurinylcarbanucleoside derivatives. Finally, three new 5-halouracilcarbanucleosides (19, 20 and 21) were prepared by reaction of uracilcarbanucleoside 18 with different N-halosuccinimides. All of the new analogues were evaluated for antiviral activity against a wide variety of viruses
PB MDPI
SN 3-906980-20-0
YR 2008
FD 2008
LK http://hdl.handle.net/10347/26850
UL http://hdl.handle.net/10347/26850
LA eng
NO Alonso, N.; Caamaño, O.; Fernández, F.; García-Mera, X.; Morales, M.; Rodríguez-Borges, J.E.; De Clercq, E. Synthesis and Antiviral Activities of Novel Purinyl- and Pyrimidinylcarbanucleosides Derived from Indan, in Proceedings of the 12th International Electronic Conference on Synthetic Organic Chemistry, 1–30 November 2008, MDPI: Basel, Switzerland, doi:10.3390/ecsoc-12-01237
NO The 12th International Electronic Conference on Synthetic Organic Chemistry session Bioorganic Chemistry and Natural Products
NO The authors thank the Xunta de Galicia for financial support of this work under projects PGIDT05PXIB20301PR and 07CSA008203PR
DS Minerva
RD 25 abr 2026