RT Journal Article
T1 Metal-promoted synthetic chemistry within living cells
A1 Miguel Ávila, Joan
A1 Tomás Gamasa, María
A1 Mascareñas Cid, José Luis
K1 Bioorthogonal chemistry
K1 Chemical biology
K1 Organometallic catalysis
K1 Intracellular reactions
AB The ability to perform 'new-to-nature' chemical reactions within living cells and organisms is transforming the way in which scientists interrogate and/or manipulate biological processes. In recent years, the toolbox of bioorthogonal and cell-compatible reactions has been enriched with the incorporation of transition metal-mediated processes. Whereas the efficiency of these reactions is still low, the breadth and generality of organometallic catalysis promises to significantly impact the field of bioorthogonal chemistry. Particularly attractive is the possibility of using organometallic catalysis for performing bond-forming, synthetically relevant reactions, as this could allow assembly of biorelevant products at specific biological sites
PB New York Elsevier, Inc
SN 2589-7209
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30681
UL http://hdl.handle.net/10347/30681
LA eng
NO Miguel-Ávila, J.; Tomás-Gamasa, M.; Mascareñas, J. L. (2023), Metal-promoted synthetic chemistry within living cells. Trends Chem., 5(6): 474–485. doi: 10.1016/j.trechm.2023.04.001
DS Minerva
RD 22 abr 2026