RT Book,_Section
T1 Triethyl ammonium sulphate catalyst one pot, Solvent free synthesis of novel Coumarin derivatives as antimicrobial agents
A1 Nikalje, Anna Pratima G.
A1 Tiwari, Shailee V.
A1 Seijas Vázquez, Julio Antonio
A1 Vázquez Tato, María del Pilar
K1 Triethyl ammonium sulphate
K1 Coumarin
K1 Anti-fungal activity
K1 Antibacterial activity
AB The work reports synthesis of 15 novel 3-((dicyclohexylamino)(substituted phenyl/heteryl)methyl)-4-hydroxy-2H-chromen-2-one derivatives 4 (a-o) as potential antimicrobial agents in solvent-free condition using Triethyl ammonium sulphate [Et3NH][HSO4] as an efficient, eco-friendly and reusable catalyst. Compared to other methods, this new method consistently has advantages, including excellent yields, a short reaction time, mild reaction conditions and catalyst reusability. The heterocyclic compound Coumarin, is associated with diverse biological activities of immense importance. Due to the presence of coumarin moiety in various pharmaceutically active compounds, we planned the green synthesis of a series of 15 novel compounds containing coumarin moiety coupled with dicyclohexyl rings by an eco-friendly ionic-liquid mediated protocol at room temperature by stirring. The structures of the synthesized compounds were confirmed by spectral characterization such as IR, 1H NMR, 13CNMR and Mass spectral studies. All the synthesized compounds 4 (a-o) were evaluated for anti-fungal and antibacterial activities and have exhibited promising antimicrobial activity
PB MDPI
SN 978-3-03842-192-4
YR 2016
FD 2016
LK http://hdl.handle.net/10347/25636
UL http://hdl.handle.net/10347/25636
LA eng
NO Nikalje, A.P., Tiwari, S, Seijas Vázquez, J.A. & Vazquez-Tato, M. P. (2016). Triethyl ammonium sulphate catalyst one pot, Solvent free synthesis of novel Coumarin derivatives as antimicrobial agents. In J.A. Seijas, M.P. Vázquez Tato y S.K. Lin. (Ed.), Proceedings ECSOC-20: The 20Th International Electronic Conference On Synthetic Organic Chemistry: November 1-30, 2016. MDPI. doi: 10.3390/ecsoc-20-f010
NO The 20th International Electronic Conference on Synthetic Organic Chemistry session Ionic Liquids
DS Minerva
RD 4 may 2026