RT Journal Article
T1 High serum cyclophilin C levels as a risk factor marker for coronary artery disease
A1 Alfonso Rancaño, María Amparo
A1 Bayón Lorenzo, Jeremías
A1 Gegunde Mosquera, Sandra
A1 Alonso López, Eva
A1 Alvariño Romero, Rebeca
A1 Santás Álvarez, Melisa
A1 Testa Fernández, Ana
A1 Ríos Vázquez, Ramón
A1 González Juanatey, Carlos
A1 Botana López, Luis Miguel
K1 Cyclophilins
K1 Coronary artery disease
AB Cyclophilins (Cyps) are ubiquitous proteins that belong to the immunophilins family consistentlyassociated with infammatory and cardiovascular diseases. While levels of CypA have been extensivelystudied, less data are available for other Cyps. The purpose of this case-control study was to determinethe relationship of Cyps (A, B, C and D) with coronary artery disease (CAD) and eight infammationmarkers. Serum levels of Cyps, interleukins and metalloproteinases were measured in serum collectedfrom 84 subjects. Participants were divided into two sub-groups based on CAD diagnosis: 40 CADpatients and 44 control volunteers. Serum levels of CypA, CypB and CypC, IL-1β and IL-6 weresignifcantly higher in CAD patients. Bivariate correlation analysis revealed a signifcant positivecorrelation between Cyps and several blood and biochemical parameters. When the ability of Cyps levelsfor CAD diagnosis was evaluated, higher sensitivity and selectivity values were obtained with CypC(c-statistic 0.891, p<0.001) indicating that it is a good marker of CAD disease, while less conclusiveresults were obtained with CypA (c-statistic 0.748, p<0.001) and CypB (c-statistic 0.655, p<0.014). Inaddition, signifcant correlations of traditional CAD risk factors and CypC were observed. In summary,high levels of CypC are a risk factor for CAD and therefore it can be proposed as a new biomarker for thisdisease
PB Nature Publishing Group
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21391
UL http://hdl.handle.net/10347/21391
LA eng
NO Alfonso, A., Bayón, J., Gegunde, S. et al. High Serum Cyclophilin C levels as a risk factor marker for Coronary Artery Disease. Sci Rep 9, 10576 (2019). https://doi.org/10.1038/s41598-019-46988-x
NO The research leading to these results has received funding from the following FEDER cofunded-grants. From Conselleria de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, 2017 GRC GI-1682 (ED431C 2017/01). From CDTI and Technological Funds, supported by Ministerio de Economía, Industria y Competitividad, AGL2016-78728-R (AEI/FEDER, UE), ISCIII/PI16/01830, ISCIII/PI16/01816 and RTC-2016-5507-2, ITC-20161072. From European Union POCTEP 0161-Nanoeaters -1-E-1, Interreg AlertoxNet EAPA-317-2016, Interreg Agritox EAPA-998-2018, and H2020 778069-EMERTOX. Sandra Gegunde was supported by a fellowship from FIDIS, Spain
DS Minerva
RD 1 may 2026