RT Journal Article
T1 Prognostic and survival factors in head and neck extra-nodal non-Hodgkin's lymphoma
A1 Bello Castro, Alba
A1 Mosquera Orgueira, Adrián
A1 Gude Sampedro, Francisco
A1 Varela Aneiros, Iván
A1 Seoane Romero, Javier
A1 Martín Biedma, Benjamín
A1 Castelo Baz, Pablo
AB Objective: To make a clinical-biological characterization of this pathology and assess the survival of these patients and the associated prognostic factors. Study design: A retrospective observational study was designed to identify primary extranodal non-Hodgkin lymphomas of the head and neck diagnosed between January 1, 2005, and January 1, 2016. Cases were considered if they presented with a single tumor in situ or if the extranodal component was clinically predominant. Results: A total of 145 patients were included. Localized stages (I-II) were present in 69.3%. Overall, 91.8% were B-cell phenotype, with diffuse large B-cell lymphoma being the most frequent. Overall, 78% of patients were treated with immunochemotherapy. The overall survival at 3 and 5 years was 75% and 73%, respectively. Adverse prognostic factors were: low hemoglobin, elevated ß2-microglobulin, and lactate dehydrogenase (LDH) levels, Eastern Cooperative Oncology Group (ECOG), stage III/IV, and B symptomatology at diagnosis. The progression-free survival at 3 and 5 years was 71% and 68%. Risk factors for relapse were high ß2-microglobulin, high LDH, and stage III-IV at diagnosis. Conclusions: These pathologies show a good response to treatment with immuno-polychemotherapy. Factors associated with a worse prognosis included low hemoglobin, elevated levels of ß2-microglobulin and LDH, elevated ECOG, stage III/IV, and B symptomatology at diagnosis.
PB Elsevier
YR 2024
FD 2024-09-11
LK https://hdl.handle.net/10347/40268
UL https://hdl.handle.net/10347/40268
LA eng
NO Bello-Castro A, Mosquera-Orgueira A, Gude-Smpedro F, Varela-Aneiros I, Seoane-Romero J, Martin-Biedma B, Castelo-Baz P. Prognostic and survival factors in head and neck extra-nodal non-Hodgkin's lymphoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2025 Feb;139(2):201-210. doi: 10.1016/j.oooo.2024.09.007
DS Minerva
RD 28 abr 2026