RT Journal Article
T1 A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance
A1 Martins, Luís
A1 Seoane-Collazo, Patricia
A1 Contreras, Cristina
A1 González García, Ismael
A1 Martínez Sánchez, Noelia
A1 González, Francisco
A1 Zalvide Torrente, Juan Bautista
A1 Gallego, Rosalía
A1 Diéguez González, Carlos
A1 Nogueiras Pozo, Rubén
A1 Tena-Sempere, Manuel
A1 López Pérez, Miguel A.
AB AMP-activated protein kinase (AMPK) in the ventromedial nucleus of the hypothalamus (VMH) and orexin (OX) in the lateral hypothalamic area (LHA) modulate brown adipose tissue (BAT) thermogenesis. However, whether these two molecular mechanisms act jointly or independently is unclear. Here, we show that the thermogenic effect of bone morphogenetic protein 8B (BMP8B) is mediated by the inhibition of AMPK in the VMH and the subsequent increase in OX signaling via the OX receptor 1 (OX1R). Accordingly, the thermogenic effect of BMP8B is totally absent in ox-null mice. BMP8B also induces browning of white adipose tissue (WAT), its thermogenic effect is sexually dimorphic (only observed in females), and its impact on OX expression and thermogenesis is abolished by the knockdown of glutamate vesicular transporter 2 (VGLUT2), implicating glutamatergic signaling. Overall, our data uncover a central network controlling energy homeostasis that may be of considerable relevance for obesity and metabolic disorders
PB Elsevier
SN 2211-1247
YR 2016
FD 2016-08-11
LK http://hdl.handle.net/10347/15980
UL http://hdl.handle.net/10347/15980
LA eng
NO 3. Martins L, Seoane-Collazo P, Contreras C, González-García I, Martínez-Sánchez N, González F et al. A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance. Cell Reports. 2016;16(8):2231-2242
NO The research leading to these results received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement 281854 the ObERStress project (M.L.), Junta de Andalucía (M.T.-S., P08-CVI-03788 and P12-FQM-01943), Xunta de Galicia (M.L., 2015-CP079; and R.N., 2015-CP080 and PIE13/00024), MINECO co-funded by FEDER (C.D., BFU2014-55871-P; R.N., BFU2015-70664-R; M.T.-S., BFU2014-57581-P; and M.L., SAF2015-71026-R and BFU2015-70454-REDT/Adipoplast). I.G.-G. is a recipient of a fellowship from Ministerio de Educación, Cultura y Deporte (FPU12/01827). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
DS Minerva
RD 24 abr 2026