RT Journal Article
T1 Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra
A1 Miguel Gordo, María
A1 Gegunde Mosquera, Sandra
A1 Calabro, Kevin
A1 Jennings, Laurence K.
A1 Alfonso Rancaño, María Amparo
A1 Genta-Jouve, Grégory
A1 Vacelet, Jean
A1 Botana López, Luis Miguel
A1 Thomas, Olivier P.
K1 Futuna
K1 Porifera
K1 Narrabeena
K1 Coral reefs
K1 Aromatic alkaloids
K1 Bromotryptamine
K1 Bromotyramine
K1 Neuroprotective agents
AB So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first chemical investigation of the sponge Narrabeena nigra collected around the Futuna Islands yielded 18 brominated alkaloids: seven new bromotryptamine derivatives 1–7 and one new bromotyramine derivative 8 together with 10 known metabolites of both families 9–18. Their structures were deduced from extensive analyses of nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS) data. In silico metabolite anticipation using the online tool MetWork revealed the presence of a key and minor biosynthetic intermediates. These 18 compounds showed almost no cytotoxic effect up to 10 µM on human neuroblastoma SH-SY5Y and microglia BV2 cells, and some of them exhibited an interesting neuroprotective activity by reducing oxidative damage
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21311
UL http://hdl.handle.net/10347/21311
LA eng
NO Miguel-Gordo, M.; Gegunde, S.; Calabro, K.; Jennings, L.K.; Alfonso, A.; Genta-Jouve, G.; Vacelet, J.; Botana, L.M.; Thomas, O.P. Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra. Mar. Drugs 2019, 17, 319
NO We are keen to thank the commitment of the people and the following institutions for their financialand scientific support that made this singular expedition possible: CNRS, PSL, CSM, EPHE, Genoscope/CEA,Inserm, Université Cote d’Azur, ANR, agnès b., UNESCO-IOC, the Veolia Environment Foundation, RégionBretagne, Serge Ferrari, Billerudkorsnas, Amerisource Bergen Company, Lorient Agglomeration, Oceans byDisney, the Prince Albert II de Monaco Foundation, L’Oréal, Biotherm, France Collectivités, Kankyo Station,Fonds Français pour l’Environnement Mondial (FFEM), Etienne BOURGOIS, the Tara Foundation teams andcrew. Tara Pacific would not exist without the continuous support of the participating institutes. Part of thisproject (Grant-Aid Agreement No. PBA/MB/16/01) is carried out with the support of the Marine Institute and isfunded under the Marine Research Program by the Irish Government. M.M.G. acknowledges James HardimanResearch Scholarship (NUI Galway) for supporting her Ph.D. The research leading to the results on bioassays hasreceived funding from the following FEDER co-funded grants: Consellería de Cultura, Educación e OrdenaciónUniversitaria Xunta de Galicia, 2017 GRC GI-1682 (ED431C 2017/01); CDTI and Technological Funds, supportedby Ministerio de Economía, Industria y Competitividad, AGL2014-58210-R, AGL2016-78728-R (AEI/FEDER, UE),ISCIII/PI16/01830 and RTC-2016-5507-2, ITC-20161072. From European Union POCTEP 0161-Nanoeaters-1-E-1,Interreg AlertoxNet EAPA-317-2016, Interreg Agritox EAPA-998-2018 and H2020 778069- EMERTOX. S.G. wassupported by a fellowship from FIDIS, Spain
DS Minerva
RD 24 abr 2026