RT Journal Article
T1 Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
A1 Caminos, Jorge E.
A1 Bravo López, Susana Belén
A1 González Dieguez, Carmen Ruth
A1 Garcés, Maria F.
A1 Cepeda, Libia A.
A1 González, Adriana C.
A1 Codido, Fernando
A1 López Pérez, Miguel A.
A1 Diéguez González, Carlos
K1 Reverse Transcription Polymerase Chain Reaction
K1 Food Restriction
K1 POMC Expression
K1 Chronic Food Restriction
K1 Agouti Related Peptide
AB BackgroundNeuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta.MethodsIn the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction.ResultsOur results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction.ConclusionThese data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy
PB BMC
SN 1477-7827
YR 2008
FD 2008
LK http://hdl.handle.net/10347/22884
UL http://hdl.handle.net/10347/22884
LA eng
NO Caminos, J.E., Bravo, S.B., González, C.R. et al. Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta. Reprod Biol Endocrinol 6, 14 (2008)
NO This work has been supported by grants from Xunta de Galicia (ML: GRC2006/66), Fondo Investigationes Sanitarias (ML: PI061700), Ministerio de Educacion y Ciencia (CD: BFU2005), Mútua Madrileña (CD and ML) and European Union (CD: LSHM-CT-2003-503041)
DS Minerva
RD 28 abr 2026