RT Journal Article
T1 Rh(III)-Catalyzed Tandem C-H Allylation and Oxidative Cyclization of Anilides: A New Entry to Indoles
A1 Cajaraville Leiro, Ana
A1 López Estévez, Susana
A1 Varela Carrete, Jesús Ángel
A1 Saá Rodríguez, Carlos
K1 Cyclization
K1 Indoles
K1 Inorganic carbon compounds
K1 Oxidative cyclization
K1 Allyl group
AB RhIII-catalyzed tandem C-H allylation and oxidative cyclization of anilides with allyl carbonates in the presence of a slight excess of AgSbF6 salt and Cu(OAc)2 as oxidant affords easy, economical access to important bioactive 2-methylindoles. The new reaction supports a wide range of functional groups on the anilide substrate. A possible mechanism is proposed as a basis for its rational further development.
PB American Chemical Society
SN 1523-7060
YR 2013
FD 2013
LK http://hdl.handle.net/10347/23342
UL http://hdl.handle.net/10347/23342
LA eng
NO Cajaraville, A., López, S., Varela, J. A., Saá, C. (2013). Rh(III)-Catalyzed Tandem C-H Allylation and Oxidative Cyclization of Anilides: A New Entry to Indoles. Org. Lett., 15, 17, 4576-4579
NO NOTICE: This is the peer reviewed version of the following article: Cajaraville, A., López, S., Varela, J. A., Saá, C. (2013). Rh(III)-Catalyzed Tandem C-H Allylation and Oxidative Cyclization of Anilides: A New Entry to Indoles. Org. Lett., 15, 17, 4576-4579. [doi: 10.1021/ol402125t]. This article may be used for non-commercial purposes in accordance with American Chemical Society Terms and Conditions for self-archiving
NO This work was supported by MICINN [projects CTQ2011-28258 and Consolider Ingenio 2010 (CSD2007-00006)] and Xunta de Galicia (projects CN2011/054 and EM 2012/051). We thank M. J. Cotón for preliminary experiments. A.C. thanks Ministerio de Ciencia e Innovación for a FPI predoctoral fellowship
DS Minerva
RD 24 abr 2026