RT Dissertation/Thesis T1 Multi-state models for biomedical research : new contributions in statistical modelling, software development, and applications A1 Machado, Luís Filipe Meira A2 Universidade de Santiago de Compostela. Facultade de Matemáticas, A2 Universidade de Santiago de Compostela. Departamento de Estatística e Investigación Operativa, K1 Medicina K1 Modelos estatísticos K1 Markov, Procesos de AB This thesis contains some co ntributions for statistical models studying the disease progression. Methods developed in this thesis are largely motivated by the applications to the medical sciences. Disease progression can be well described using multi-state models. These models may be considered as a generalization of the survival process where several (intermediate) events occur successively over time. Multi-state models offer a better understanding of the process of the illness, leading to a better knowledge of the evolution of the disease over time. YR 2005 FD 2005 LK http://hdl.handle.net/10347/9637 UL http://hdl.handle.net/10347/9637 LA eng DS Minerva RD 24 abr 2026