RT Journal Article
T1 The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines
A1 Gutiérrez Lovera, Carlha Rodmar
A1 Vázquez Ríos, Abi Judit
A1 Guerra Varela, Jorge
A1 Sánchez Piñón, Laura
A1 Fuente Freire, María de la
K1 Nanomedicines
K1 Cancer
K1 Gene therapies
K1 Zebrafish
K1 Translation
AB In the last few decades, the field of nanomedicine applied to cancer has revolutionized cancer treatment: several nanoformulations have already reached the market and are routinely being used in the clinical practice. In the case of genetic nanomedicines, i.e., designed to deliver gene therapies to cancer cells for therapeutic purposes, advances have been less impressive. This is because of the many barriers that limit the access of the therapeutic nucleic acids to their target site, and the lack of models that would allow for an improvement in the understanding of how nanocarriers can be tailored to overcome them. Zebrafish has important advantages as a model species for the study of anticancer therapies, and have a lot to offer regarding the rational development of efficient delivery of genetic nanomedicines, and hence increasing the chances of their successful translation. This review aims to provide an overview of the recent advances in the development of genetic anticancer nanomedicines, and of the zebrafish models that stand as promising tools to shed light on their mechanisms of action and overall potential in oncology
PB MDPI
YR 2017
FD 2017
LK http://hdl.handle.net/10347/26107
UL http://hdl.handle.net/10347/26107
LA eng
NO Genes 2017, 8(12), 349; https://doi.org/10.3390/genes8120349
NO This work was supported by the Xunta de Galicia, Spain (Competitive Reference Groups, GRC2014/010), the Carlos III Health Institute/FEDER (PI15/00828), and the Spanish Ministry of Education, Culture and Sport (FPU15/06595)
DS Minerva
RD 24 abr 2026