RT Journal Article
T1 Patents on Quorum Quenching: Interfering with Bacterial Communication as a Strategy to Fight Infections
A1 Romero Bernárdez, Manuel
A1 Acuña, Laura
A1 Otero Casal, Ana María
K1 Acylase
K1 Agonist
K1 AHL
K1 AI-2
K1 Antagonist
K1 Bacterial communication
K1 Biofilm
K1 Lactonase
K1 Peptide
K1 Quorum quenching
K1 Quorum sensing
K1 Signal
K1 Virulence
AB Numerous bacterial functions, such as virulence and biofilm formation, are controlled by a cell densitydependent communication mechanism known as Quorum Sensing (QS), in which small diffusible molecules are released, allowing bacteria to coordinate their behavior once a minimal effective quorum has been reached. The interference with these signaling systems, also known as Quorum Quenching (QQ), represents a promising strategy to tackle bacterial infections. The growing interest in this approach is reflected by the increasing number of patents within the field (45 up to now), especially in the last few years, as shown by patent applications published since 2009. The fact that biofilm formation is also controlled by QS systems expands the application of QQ to clinically-relevant biofilms such as those responsible for periodontal disease. Moreover, since biofilms increase bacterial resistance to antimicrobials, QQ could represent a new way to fight some of the most recurrent human pathogens, such as nosocomial multiresistant strains, and this deserves further exploration, especially through more proofs of concept. In this article we review the best known QS and QQ systems to date and we describe recent patents on the interference with this type of bacterial communication.
PB Bentham Science Publishers
YR 2012
FD 2012
LK https://hdl.handle.net/10347/41657
UL https://hdl.handle.net/10347/41657
LA eng
NO The published manuscript is available at EurekaSelect via https://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/187220812799789208
NO This work was financially supported by Fundación Barrié de la Maza.
DS Minerva
RD 25 abr 2026