RT Journal Article
T1 Novel Supramolecular Nanoparticles Derived From Cucurbit[7]uril and Zwitterionic Surfactants
A1 Fernández Rosas, Josefa
A1 Pessêgo, Márcia Isabel Duarte
A1 Acuña, Angel
A1 Vázquez-Vázquez, Carlos
A1 Montenegro García, Javier
A1 Parajo, Mercedes
A1 Rodriguez-Dafonte, Pedro
A1 Nome, Faruk
A1 García Río, Luis
AB Binding constants, Log K ≈ 6.6 M-1, and NMR characterization of the complexes formed by sulfobetaines and cucurbit[7]uril (CB7) support the electrostatic interaction as major driving force. This very strong binding motif is cross-linked by additional CB7 molecules resulting in the formation of supramolecular nanoparticles (SNPs) with an average diameter of 172 nm and negative surface potential. The time course evolution of the particle size and the surface potential suggests the very fast formation of an amorphous aggregate that absorbs additional amount of sulfobetaine. These aggregates afford very stable (more than two weeks) nanoparticles in aqueous dispersion. The reversibility of the sulfobetaine/CB7 host:guest complexes allows SNPs disaggregation by adding a competitive guest as shown by treatment with tetraethylammonium chloride. The addition of this competitive cation triggers a SNPs to micelle transition. The potential application of these nanoparticles as drug delivery vehicles was investigated by using carboxyfluorescein. These experiments revealed that upon externally induced disruption of the SNPs (by tetraethylammonium chloride) the fluorescent dye was trapped into micellar aggregates that can be further disrupted by cyclodextrin additionhttp://www.usc.es/
PB American Chemistry Society
SN 0743-7463
YR 2018
FD 2018-02-12
LK http://hdl.handle.net/10347/16565
UL http://hdl.handle.net/10347/16565
LA eng
NO Fernández-Rosas, J., Pessego, M., Acuña, A., Vazquez-Vazquez, C., Montenegro, J., & Parajo, M. et al. (2018). Novel Supramolecular Nanoparticles Derived From Cucurbit[7]uril and Zwitterionic Surfactants. Langmuir. http://dx.doi.org/10.1021/acs.langmuir.7b04234
NO Financial support from Ministerio de Economia y Competitividad of Spain (projectsCTQ2014-55208-P, CTQ2017-84354-P, CTQ2014-59646-R and MAT2015-67458-P),Xunta de Galicia (GR 2007/085; IN607C 2016/03 and Centro singular de investigaciónde Galicia accreditation 2016-2019, ED431G/09) and the European Union (EuropeanRegional Development Fund – ERDF), is gratefully acknowledged. J.M. received aRamón y Cajal (RYC-2013- 13784) and a starting grant from the ERC (DYNAP677786)
DS Minerva
RD 24 abr 2026