RT Journal Article
T1 Neuroendocrine pathways at risk? Simvastatin induces inter and transgenerational disruption in the keystone amphipod Gammarus locusta
A1 Neuparth, Teresa
A1 Alves, Nélson
A1 Machado, Andrade M.
A1 Pinheiro, Marlene
A1 Montes Goyanes, Rosa
A1 Rodil Rodríguez, María del Rosario
A1 Barros, Susana
A1 Ruivo, Raquel
A1 Castro, Luis Filipe
A1 Quintana Álvarez, José Benito
A1 Santos, Miguel Machado
K1 Simvastatin
K1 Gammarus locusta
K1 Neuroendocrine signaling pathways
K1 Transcriptomic
K1 Inter and transgenerational effects
K1 Regulatory agencies
AB The primary focus of environmental toxicological studies is to address the direct effects of chemicals on exposed organisms (parental generation – F0), mostly overlooking effects on subsequent non-exposed generations (F1 and F2 – intergenerational and F3 transgenerational, respectively). Here, we addressed the effects of simvastatin (SIM), one of the most widely prescribed human pharmaceuticals for the primary treatment of hypercholesterolemia, using the keystone crustacean Gammarus locusta. We demonstrate that SIM, at environmentally relevant concentrations, has significant inter and transgenerational (F1 and F3) effects in key signaling pathways involved in crustaceans’ neuroendocrine regulation (Ecdysteroids, Catecholamines, NO/cGMP/PKG, GABAergic and Cholinergic signaling pathways), concomitantly with changes in apical endpoints, such as depressed reproduction and growth. These findings are an essential step to improve hazard and risk assessment of biological active compounds, such as SIM, and highlight the importance of studying the transgenerational effects of environmental chemicals in animals’ neuroendocrine regulation
PB Elsevier
SN 0166-445X
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29220
UL http://hdl.handle.net/10347/29220
LA eng
NO T. Neuparth et al. Aquatic Toxicology, 2022, 244, 106095
NO This work was financially supported by: i) Transobesogen Project – “Trans-phyletic obesogenic responses: from epigenetic modules to transgenerational environmental impacts” reference: PTDC/CTA-AMB/31544/2017 – NORTE-01–0145-FEDER-031544, co-financed by the Portuguese Foundation for Science and Technology (FCT), North Regional Operational Program (NORTE 2020) and the European Regional Development Fund (FEDER). ii) Nor-Water Project – “Poluentes emergentes nas águas da Galiza-Norte de Portugal: novas ferramentas para gestão de risco” reference: 0725_NOR_WATER_1_P financed by INTERREG VA Spain-Portugal cooperation program, Cross-Border North Portugal/Galizia Spain Cooperation Program (POCTEP) 2014–2020. iii) the National Funds through FCT under the projects (UIDB/04423/2020; UIDP/04423/2020). Nélson Alves acknowledges FCT for his Ph.D. grant DFA/BD/6218/2020. Andre M Machado acknowledges FCT for his Ph.D. grant DFA/BD/8069/2020. Marlene Pinheiro acknowledges FCT for her Ph.D. grant SFRH/BD/147834/2019. Susana Barros acknowledges FCT for her Ph.D. grant PD/BD/143090/2018. Financial support by Xunta de Galicia (ED431C2021/06) and the Spanish Agencia Estatal de Investigación - AEI (PID2020–117686RB-C32) is also gratefully acknowledged.
DS Minerva
RD 24 abr 2026