RT Journal Article
T1 Factors associated with underreporting of adverse drug reactions by health care professionals: a systematic review update
A1 García Abeijon, Patricia
A1 Costa, Ana Catarina Silva
A1 Taracido Trunk, Margarita
A1 Herdeiro, Maria Teresa Ferreira
A1 Torre, Carla de Matos
A1 Figueiras Guzmán, Adolfo
K1 Drugs
K1 Adverse drugs reactions
K1 Health professionals
AB IntroductionUnderreporting is a major limitation of the voluntary reporting system of adverse drug reactions (ADRs). A 2009 systematic review showed the knowledge and attitudes of health professionals were strongly related with underreporting of ADRs.ObjectiveOur aim was to update our previous systematic review to determine factors (sociodemographic, knowledge and attitudes) associated with the underreporting of ADRs by healthcare professionals.MethodsWe searched the MEDLINE and EMBASE databases for studies published between 2007 and 2021 that met the following inclusion criteria: (1) published in English, French, Portuguese or Spanish; (2) involving health professionals; and (3) the goal was to evaluate factors associated with underreporting of ADRs through spontaneous reporting.ResultsOverall, 65 papers were included. While health professional sociodemographic characteristics did not influence underreporting, knowledge and attitudes continue to show a significant effect: (1) ignorance (only serious ADRs need to be reported) in 86.2%; (2) lethargy (procrastination, lack of interest, and other excuses) in 84.6%; (3) complacency (the belief that only well tolerated drugs are allowed on the market) in 46.2%; (4) diffidence (fear of appearing ridiculous for reporting merely suspected ADRs) in 44.6%; and (5) insecurity (it is nearly impossible to determine whether or not a drug is responsible for a specific adverse reaction) in 33.8%, and the absence of feedback in 9.2%. In this review, the non-obligation to reporting and confidentiality emerge as new reasons for underreporting.ConclusionsAttitudes regarding the reporting of adverse reactions continue to be the main determinants of underreporting. Even though these are potentially modifiable factors through educational interventions, minimal changes have been observed since 2009
PB Springer
SN 0114-5916
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30870
UL http://hdl.handle.net/10347/30870
LA eng
NO García-Abeijon, P., Costa, C., Taracido, M. et al. Factors Associated with Underreporting of Adverse Drug Reactions by Health Care Professionals: A Systematic Review Update. Drug Saf 46, 625–636 (2023). https://doi.org/10.1007/s40264-023-01302-7
NO Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study has been funded in part by the Instituto de Salud Carlos III (ISCIII) through the project PI19/01006, cofinanced by FEDER, European Union
DS Minerva
RD 27 abr 2026