RT Journal Article T1 Single-chamber pacemakers: with or without leads? Cost-effectiveness and cost-utility analyses A1 Lago Quinteiro, José Ramón A1 Reyes Santias, Francisco A1 Antelo Suárez, Manel A1 Caballer Tarazona, Vicent A1 Martínez Sande, José Luis A1 García Seara, Javier A1 Rodríguez Mañero, Moisés A1 González Juanatey, José Ramón K1 Conventional pacemaker K1 Leadless pacemaker K1 Cost-effectiveness analysis K1 Cost-utility analysis AB IntroductionThe evolution in pacemaker technologies has led to improvements in size, weight, functionality, and durability, even as the battery and electrode-based structural configuration has remained essentially the same.ObjectiveTo compare the cost-effectiveness and cost-utility of conventional and leadless pacemakers.Material and methodsWe conducted a retrospective observational study of 403 patients randomly implanted with a conventional or leadless pacemaker (1 June 2015–31 January 2020) in the Hospital-University Complex of Santiago de Compostela (Galicia, NW Spain).ResultsConventional and leadless pacemakers were implanted in 244 and 159 patients, respectively. Leadless pacemakers were superior to the conventional pacemakers in terms of both cost-effectiveness and cost-utility, with incremental cost-effectiveness ratios of 6,263.38 euros per gained life year and of 5,210.71 euros per quality-adjusted life year, respectively.ConclusionsLeadless pacemakers have fewer complications than conventional pacemakers and, although the device itself is more expensive, the leadless pacemaker is more cost-effective in around 90% of cases. PB Taylor & Francis SN 1365-2060 YR 2025 FD 2025-05-29 LK https://hdl.handle.net/10347/46339 UL https://hdl.handle.net/10347/46339 LA eng NO José Ramón Lago-Quinteiro, Francisco Reyes-Santias, Manel Antelo, Vicent Caballer-Tarazona, José Luis Martinez-Sande, Javier Garcia-Seara, Moisés RodriguezManero & Jose Ramon Gonzalez-Juanatey (2025) Single-chamber pacemakers: with or without leads? Cost-effectiveness and cost-utility analyses, Annals of Medicine, 57:1, 2512108, DOI: 10.1080/07853890.2025.2512108 DS Minerva RD 20 may 2026