RT Journal Article
T1 Prosomeric organization of the hypothalamus in an elasmobranch, the catshark Scyliorhinus canicula
A1 Santos Durán, Gabriel Nicolás
A1 Menuet, Arnaud
A1 Lagadec, Ronan
A1 Mayeur, Hélène
A1 Ferreiro Galve, Susana
A1 Mazan, Sylvie
A1 Rodríguez-Moldes Rey, María Isabel
A1 Candal Suárez, Eva María
K1 Chondrichthyan
K1 Forebrain patterning
K1 Evolution
K1 Development
K1 Prosomeric model
K1 Shh
K1 Nkx2.1
K1 Otp
AB The hypothalamus has been a central topic in neuroanatomy because of its importantphysiological functions, but its mature organization remains elusive. Deciphering itsembryonic and adult organization is crucial in an evolutionary approach of theorganization of the vertebrate forebrain. Here we studied the molecular organizationof the hypothalamus and neighboring telencephalic domains in a cartilaginousfish, the catshark, Scyliorhinus canicula, focusing on ScFoxg1a, ScShh, ScNkx2.1,ScDlx2/5, ScOtp, and ScTbr1 expression profiles and on the identification αacetylated-tubulin-immunoreactive (ir), TH-ir, 5-HT-ir, and GFAP-ir structures by meansof immunohistochemistry. Analysis of the results within the updated prosomeric modelframework support the existence of alar and basal histogenetic compartments in thehypothalamus similar to those described in the mouse, suggesting the ancestralityof these subdivisions in jawed vertebrates. These data provide new insights intohypothalamic organization in cartilaginous fishes and highlight the generality of keyfeatures of the prosomeric model in jawed vertebrates.
PB Frontiers Media
YR 2015
FD 2015
LK http://hdl.handle.net/10347/22594
UL http://hdl.handle.net/10347/22594
LA eng
NO Santos-Durán GN, Menuet A, Lagadec R, Mayeur H, Ferreiro-Galve S, Mazan S, Rodríguez-Moldes I and Candal E (2015) Prosomeric organization of the hypothalamus in an elasmobranch, the catshark Scyliorhinus canicula. Front. Neuroanat. 9:37. doi: 10.3389/fnana.2015.00037
NO This work was supported by grants from the Spanish Dirección General de Investigación-FEDER (BFU2010- 15816), the Xunta de Galicia (10PXIB200051PR, CN 2012/237), European Community-Research Infrastructure Action under the FP7 “Capacities” Specific Programme (ASSEMBLE 227799), the Région Centre, Région Bretagne (EVOVERT grant number 049755; PEPTISAN project), National Research Agency (grant ANR-09-BLAN-026201), CNRS, Université d’Orléans and Université Pierre et Marie Curie. GNSD would like to thank Spanish SEPE for its funding support
DS Minerva
RD 30 abr 2026