RT Journal Article
T1 Revisiting gold nanoshells as multifunctional biomedical nanotools
A1 Topete Camacho, Antonio
A1 Varela, Alejandro
A1 Navarro Real, Mariana
A1 Rial Silva, Ramón
A1 Pardo Montero, Alberto
A1 Taboada Antelo, Pablo
K1 Gold nanoshells
K1 Gold nanoparticles
K1 Biological interactions
K1 Photothermal therapy
K1 Bioimaging
K1 Biosensing
K1 Theragnosis
AB The application of gold nanoparticles in the biomedical field has been widely explored in the last decades owing to their high biocompatibility, easy functionalization, and their structurally highly dependent optical properties. Among the different types of gold-based nanostructures, gold nanoshells (GNSs) are a particularly interesting option due to their complex dual structure, which allows the integration of several functionalities and a wide tunability of their optical response. Despite the remarkable progress made for the design of GNSs with the optimal characteristics for the intended application, the development of nanosystems that display the desired functionalities and preserve them in biological environments while showing effective targeting capability is still a challenge. In this review, the different synthetic routes proposed for the design of GNSs, their most remarkable optical properties, and the most relevant concerns associated with their interaction with biological systems are discussed. The application of these nanostructures for different diagnostic and/or therapeutic purposes is also reviewed. Finally, major remaining barriers to the clinical translation of GNSs and potential future directions of research in this field are critically commented.Graphical abstract
PB Elsevier
SN 0010-8545
YR 2024
FD 2024-10-11
LK https://hdl.handle.net/10347/39875
UL https://hdl.handle.net/10347/39875
LA eng
NO References  Topete, A., Varela, A., Navarro-Real, M., Rial, R., Pardo, A., & Taboada, P. (2025). Revisiting gold nanoshells as multifunctional biomedical nanotools. Coordination Chemistry Reviews, 52310.1016/j.ccr.2024.216250
NO A.T. thanks CONAHCYT México Ciencia de Frontera 2019: 568483; Unión Europea NextGeneration EU: María Zambrano 2022-2023. The authors also thank Agencia Estatal de Investigación for projects PID2019-109517RB-I00 and PID2023-152062OA-I00, Xunta de Galicia for projects ED431C 2022/18 and ED481B2019/025, and Fundação para a Ciência e a Tecnologia for project 2022.05526.PTDC (Wi-Pi). European Regional Development Funds are also acknowledged. Schematics in ToC, Fig. 1, Fig. 3, Fig. 5, and Fig. 7 were created with Biorender.com.
DS Minerva
RD 24 abr 2026