RT Journal Article
T1 Engineering, on-demand manufacturing, and scaling-up ofpolymeric nanocapsules
A1 Crecente Campo, José
A1 Alonso Fernández, María José
K1 High-throughput screening
K1 Layer-by-layer
K1 Microfluidics
K1 Nanocapsules
K1 Particle size
K1 Scale-up
AB Polymeric nanocapsules are versatile delivery systems with the capacity to load lipophilic drugs in their oily nucleus and hydrophilic drugs in their polymeric shell. The objective of this work was to expand the technological possibilities to prepare customized nanocapsules. First, we adapted the solvent displacement technique to modulate the particle size of the resulting nanocapsules in the 50–500 nm range. We also produced nanosystems with a shell made of one or multiple polymer layers i.e. chitosan, dextran sulphate, hyaluronate, chondroitin sulphate, and alginate. In addition, we identified the conditions to translate the process into a miniaturized high-throughput tailor-made fabrication that enables massive screening of formulations. Finally, the production of the nanocapsules was scaled-up both in a batch production, and also using microfluidics. The versatility of the properties of these nanocapsules and their fabrication technologies is expected to propel their advance from bench to clinic
PB Willey
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21333
UL http://hdl.handle.net/10347/21333
LA eng
NO Crecente‐Campo, J, Alonso, MJ. Engineering, on‐demand manufacturing, and scaling‐up of polymeric nanocapsules. Bioengineering & Translational Medicine. 2019; 4: 38– 50. https://doi.org/10.1002/btm2.10118
NO This work was funded by CDTI (Spanish Ministry of Science and Innovation) and (Fondo Tecnológico Xunta de Galicia, FEDER funds) COLIVAC-FEDER INNTERCONECTA-2012-CE277 and Grupos de referencia competitiva (ED431C 2017/09, Xunta de Galicia)
DS Minerva
RD 25 abr 2026