RT Dissertation/Thesis
T1 Structural Control of Membrane-Targeted Peptides for Delivery of Functional Proteins
A1 Pazo Pascual, Marta
K1 Peptide
K1 helical folding
K1 protein delivery
AB The plasma membrane controls the flow of bioactive molecules entering thecell. Most small molecules can easily cross plasma membranes. However, macromolecules such as proteins orantibodies with pharmacological characteristics have limited access, either by hindering internalization orendosomal escape. Therefore, during the development of this PhD thesis we designed new CPPs as transportersof this type of drugs.We investigated new CPP designs and how to modulate their cellular activity, penetration and viability capabilities.Starting with new peptide libraries through dynamic linkages to discover good ratios between cationic charge andhydrophobic residues. Moving on to designs that increase helical folding in membranes to improve internalizationand viability. Finally, to characterize the supramolecular behavior in membranes of the designed CPPs and toevaluate the capacity for transport and delivery of protein drugs.
YR 2021
FD 2021
LK http://hdl.handle.net/10347/27249
UL http://hdl.handle.net/10347/27249
LA eng
DS Minerva
RD 24 abr 2026