RT Journal Article
T1 Hydroxyapatite Nanoparticle Mesogens: Morphogenesis of pHSensitive Macromolecular Liquid Crystals
A1 Benedini, Luciano A.
A1 Moglie, Yanina
A1 Ruso Beiras, Juan Manuel
A1 Nardi, Sofía
A1 Messina, Paula V.
AB Numerous living structural materials display self-assembly of building blocks. Biological molecular networks exhibit lyotropic liquid crystalline properties that can support non-equilibrium pathways influenced by dynamic processes at the microscale. With the aim of taking a further step toward the conquest of a biomimetic material to apply in calcified tissue regeneration, in this work, we have evaluated the chemical grafting of phosphorous amide (C–N–P) and α-amino phosphonate (N–C–P) molecular fragments on previously created biomimetic hydroxyapatite (HA) nanoparticles (nano-HA). Molecular combinations were selected due to their recognized capability of influencing bone physiology and pathology. We have assessed the effect of the type and degree of nano-HA substitution over the spontaneous self-association of acidic macromolecules that respond to pH stimulation. The produced materials were inspected by Fourier transform infrared and solid-state nuclear magnetic resonance spectroscopy, small-angle X-ray scattering, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and polarized light and high-resolution electron transmission microscopy. A complete analysis of the experimental data proved that under specific synthetic conditions, it is possible to obtain substituted-HA nanoparticles that are able to act as mesogenic agents. These systems that dynamically respond to pH can be tailored in vitro to induce, at concentration values analogous to biogenic ones, lyotropic liquid crystal organization on acid macromolecules.
PB American Chemical Society
YR 2021
FD 2021-03-21
LK https://hdl.handle.net/10347/43947
UL https://hdl.handle.net/10347/43947
LA eng
NO Cryst. Growth Des. 2021, 21, 4, 2154–2166
NO This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth & Desing, copyright © 2021 American Chemical Society  after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.0c01582
NO The authors acknowledge financial support of the Universidad Nacional del Sur (UNS, PGI 24/Q092), Concejo Nacional de Investigaciones Científicas y Técnicas (CONICET, PIP-11220130100100CO), Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT, PICT 201-0126), Comisión de Investigaciones Científicas (CIC), Argentina and Xunta de Galicia (AEMAT, ED431E2018/08, and ED431B2017/21). S.N. has a training Scholarship (BENTR 2019) awarded by the CIC. L.A.B., Y.M., and P.V.M. are researchers of CONICET.
DS Minerva
RD 28 abr 2026